TP53 Arg72Pro polymorphism is associated with esophageal cancer risk: A meta-analysis

被引:18
作者
Jiang, De-Ke [1 ]
Yao, Lei [1 ]
Wang, Wen-Zhang [1 ]
Peng, Bo [1 ]
Ren, Wei-Hua [1 ]
Yang, Xian-Mei [1 ]
Yu, Long [1 ]
机构
[1] Fudan Univ, State Key Lab Genet Engn, Inst Biomed Sci, Shanghai 200433, Peoples R China
基金
中国国家自然科学基金;
关键词
TP53; Codon; 72; Polymorphism; Esophageal cancer; Meta-analysis; SQUAMOUS-CELL CARCINOMA; P53; CODON-72; POLYMORPHISM; HARDY-WEINBERG EQUILIBRIUM; GENETIC POLYMORPHISMS; GENOTYPING ERRORS; POPULATION; VARIANTS; ADENOCARCINOMA; SUSCEPTIBILITY; HETEROGENEITY;
D O I
10.3748/wjg.v17.i9.1227
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
AIM: To investigate the association between TP53 Arg72Pro polymorphism and esophageal cancer (EC) risk using meta-analysis. METHODS: All eligible studies published before March 1, 2010 were selected by searching PubMed using keywords "p53" or "TP53", "polymorphism" or "variation", "esophageal" and "cancer" or "carcinoma". Crude odds ratios (ORs) with 95% confidence intervals (CIs) were assessed for EC risk associated with TP53 Arg72Pro polymorphism using fixed- and random-effects models. RESULTS: Nine case-control studies involving 5545 subjects were included in this meta-analysis. Significantly reduced risk of EC was associated with TP53 genotypes for Arg/Arg + Arg/Pro vs Pro/Pro (OR = 0.73, 95% CI: 0.57-0.94, P = 0.014). Subgroup analyses according to the source of controls and the specimens used for determining TP53 Arg72Pro genotypes or sample size showed that significantly reduced risk was observed only in studies which have population-based controls (Arg/Arg vs Pro/Pro: OR = 0.56, 95% CI: 0.47-0.66, P < 0.001), and use white blood cells or normal tissue to assess TP53 genotypes of cases (Arg/Arg vs Pro/Pro: OR = 0.56, 95% CI: 0.47-0.65, P < 0.001) or include at least 200 subjects (Arg/Arg vs Pro/Pro: OR = 0.56, 95% CI: 0.47-0.65, P < 0.001). Analysis restricted to well-designed studies also supported the significantly decreased risk of EC (Arg/Arg vs Pro/Pro: OR = 0.54, 95% CI: 0.46-0.64, P < 0.001). CONCLUSION: TP53 Arg72 carriers are significantly associated with decreased EC risk. Nevertheless, more well-designed studies are needed to confirm our findings. (c) 2011 Baishideng. All rights reserved.
引用
收藏
页码:1227 / 1233
页数:7
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