Heme oxygenase-1 is a novel target and antioxidant mediator of S-adenosylmethionine

被引：20

作者：

Erdmann, Kati ^{[1
]}

Cheung, Belinda W. Y. ^{[1
]}

Immenschuh, Stephan ^{[2
]}

Schroeder, Henning ^{[1
]}

机构：

[1] Univ Minnesota, Coll Pharm, Dept Pharmaceut, McGuire Translat Res Facil, Minneapolis, MN 55455 USA

[2] Univ Giessen, Inst Clin Immunol & Transfus Med, D-35392 Giessen, Germany

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 368卷 / 04期

关键词：

antioxidant; endothelial cells; ferritin; heme oxygenase-1; S-adenosylmethionine;

D O I：

10.1016/j.bbrc.2008.02.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The sulfur compound and dietary supplement S-adenosylmethionine (SAM) has been reported to have cytoprotective and antioxidant properties. However, the underlying mechanisms remain unresolved. The present study investigates the effect of SAM on the expression of the antioxidant stress proteins heme oxygenase-1 (HO-1) and ferritin in endothelial cells. Induction of the HO-1/ferritin-system leads to protection of tissues against several inflammatory stimuli. SAM increased the protein and mRNA levels of HO-1 in cultured endothelial cells. Induction of HO-1 gene expression was associated with elevated ferritin protein levels and regulated at the transcriptional level via increased promoter activity. HO-1 upregulation by SAM was causally related to a decrease in NADPH-mediated production of oxygen radicals. Our results demonstrate that the HO-1/ferritin-system is a novel target of the antioxidant compound SAM. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：937 / 941

页数：5

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