The molecular control of meiotic double-strand break (DSB) formation and its significance in human infertility

被引：11
作者：
Li, Yang [1 ]
Wu, Yu-Fan [1 ]
Jiang, Han-Wei [1 ]
Khan, Ranjha [1 ]
Han, Qi-Qi [1 ]
Iqbal, Furhan [2 ]
Jiang, Xiao-Hua [1 ]
Shi, Qing-Hua [1 ]
机构：
[1] Univ Sci & Technol China, Div Reprod & Genet,CAS Ctr Excellence Mol Cell Sc, Affiliated Hosp USTC 1,Sch Basic Med Sci,Div Life, Hefei Natl Lab Phys Sci Microscale,CAS Key Lab In, Hefei 230027, Peoples R China
[2] Bahauddin Zakariya Univ, Inst Pure & Appl Biol, Multan 60000, Pakistan
来源：
ASIAN JOURNAL OF ANDROLOGY | 2021年 / 23卷 / 06期
基金：
中国国家自然科学基金;
关键词：
RECOMBINATION HOTSPOTS; CHROMOSOME SYNAPSIS; C; ELEGANS; SPO11; GENE; DNA; PROTEIN; MEIOSIS; INITIATION; PRDM9; AXIS;
D O I：
10.4103/aja.aja_5_21
中图分类号：
R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
摘要：
Meiosis is an essential step in gametogenesis which is the key process in sexually reproducing organisms as meiotic aberrations may result in infertility. In meiosis, programmed DNA double-strand break (DSB) formation is one of the fundamental processes that are essential for maintaining homolog interactions and correcting segregation of chromosomes. Although the number and distribution of meiotic DSBs are tightly regulated, still abnormalities in DSB formation are known to cause meiotic arrest and infertility. This review is a detailed account of molecular bases of meiotic DSB formation, its evolutionary conservation, and variations in different species. We further reviewed the mutations of DSB formation genes in association with human infertility and also proposed the future directions and strategies about the study of meiotic DSB formation.
引用
收藏
页码：555 / 561
页数：7
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