Biotinylated chitosan-based SPIONs with potential in blood-contacting applications

被引：36

作者：

Balan, Vera ^{[2
]}

Petrache, Ivona Andreea ^{[1
]}

Popa, Marcel Ionel ^{[2
]}

Butnaru, Maria ^{[1
]}

Barbu, Eugen ^{[3
]}

Tsibouklis, John ^{[3
]}

Verestiuc, Liliana ^{[1
]}

机构：

[1] Gr T Popa Univ Med & Pharm, Fac Med Bioengn, Dept Biomed Sci, Iasi 700454, Romania

[2] Tech Univ Gh Asachi, Fac Chem Engn & Environm Protect, Iasi 700050, Romania

[3] Univ Portsmouth, Sch Pharm & Biomed Sci, Portsmouth PO1 2DT, Hants, England

来源：

JOURNAL OF NANOPARTICLE RESEARCH | 2012年 / 14卷 / 02期

关键词：

SPIONs; Magnetite; Chitosan; Biotin; Blood-contacting applications; Nanobiotechnology; IRON-OXIDE NANOPARTICLES; MAGNETIC NANOPARTICLES; TPP NANOPARTICLES; COAGULATION; FIBROBLASTS; DELIVERY; DEXTRAN; SYSTEM;

D O I：

10.1007/s11051-012-0730-y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Haemocompatible biotinylated superparamagnetic nanoparticles (size range 300-700 nm) have been obtained by coating magnetite through ionic gelation with a mixture of chitosan and sodium tripolyphosphate, followed by subsequent functionalisation with biotin. The evaluations of their magnetic properties together with haemocompatibility tests have shown that these nanoparticles exhibit the prerequisite behaviour for use in magnetic field-assisted separations within biological systems.

引用

页数：14

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