Macular Telangiectasia Type 2: A Comprehensive Review

被引：11
|
作者：
Kedarisetti, Kiran Chandra [1 ]
Narayanan, Raja [1 ,2 ,6 ]
Stewart, Michael W. [3 ]
Gurram, Nikitha Reddy [1 ]
Khanani, Arshad M. [4 ,5 ]
机构：
[1] LV Prasad Eye Inst, Anant Bajaj Retina Inst, Hyderabad, Telangana, India
[2] Publ Hlth & Econ Res Ctr IHOPE, Indian Hlth Outcomes, Hyderabad, Telangana, India
[3] Mayo Clin, Dept Ophthalmol, Jacksonville, FL USA
[4] Sierra Eye Associates, Dept Clin Res, Reno, NV USA
[5] Univ Nevada, Dept Ophthalmol, Reno, NV USA
[6] L V Prasad Eye Inst, Anant Bajaj Retina Inst, Hyderabad, Telangana, India
来源：
CLINICAL OPHTHALMOLOGY | 2022年 / 16卷
关键词：
macular telangiectasia type 2; MacTel; CNTF; ciliary neurotrophic factor; OPTICAL COHERENCE TOMOGRAPHY; SUBRETINAL NEOVASCULARIZATION SECONDARY; JUXTAFOVEOLAR RETINAL TELANGIECTASIS; INTRAVITREAL BEVACIZUMAB THERAPY; GRID LASER PHOTOCOAGULATION; GROWTH-FACTOR THERAPY; PHOTODYNAMIC THERAPY; SUBFOVEAL NEOVASCULARIZATION; FUNDUS AUTOFLUORESCENCE; FLUORESCEIN-ANGIOGRAPHY;
D O I：
10.2147/OPTH.S373538
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Macular telangiectasia Type 2 (MacTel) is a gradually progressive disease that affects the quality of life by impairing both distant and near vision. It had previously been considered a vascular condition, but recent evidence suggests a neurodegenerative etiology, with primary involvement of Muller cells. Retinal pigment epithelium (RPE) hyperplasia and subretinal neovascularization (SNV) are responsible for most of the vision loss in advanced cases. Neurotrophic factors in the non-proliferative phase and intravitreal anti-Vascular Endothelial growth factor (VEGF) in the proliferative phase have shown to retard the progression of the disease. This review will discuss the pathophysiology, clinical features, important diagnostic imaging studies and available treatment options for MacTel.
引用
收藏
页码：3297 / 3309
页数：13
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