The Role of Histone H3 Methylation in Acute Kidney Injury

被引：8

作者：

Zhao, Yi-Bo ^{[1
]}

Wei, Wei ^{[1
]}

Lin, Xiao-Xi ^{[1
]}

Chai, Yan-Fen ^{[1
,2
]}

Jin, Heng ^{[1
,2
]}

机构：

[1] Tianjin Med Univ, Dept Emergency Med, Gen Hosp, Tianjin 300000, Peoples R China

[2] Tianjin Med Univ, Dept Emergency Med, Gen Hosp, Tianjin 300000, Peoples R China

来源：

DRUG DESIGN DEVELOPMENT AND THERAPY | 2022年 / 16卷

基金：

中国国家自然科学基金;

关键词：

kidney; Acute kidney injury; histone methylation; epigenetic; ATTENUATES RENAL FIBROSIS; REPERFUSION INJURY; INHIBITION; PROGRESSION; ACTIVATION; KLOTHO; DEFICIENCY; ISCHEMIA; THERAPY;

D O I：

10.2147/DDDT.S376673

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Acute kidney injury (AKI) is a clinical syndrome in which kidney function declines sharply due to various reasons. Although the morbidity and mortality of AKI are high, the mechanism of occurrence and development of AKI has not been fully elucidated, and precise prevention and treatment measures are lacking. Epigenetics is a branch of genetics that provides a new perspective to explore the pathophysiology of AKI and renal repair. A large amount of literature shows that the methylation mechanism of H3 in histones is closely related to the development of kidney diseases. The sorting out of histone H3 methylation mechanism in AKI and kidney repair can help understand the pathophysiological process of the disease more deeply. It may also provide new ideas for diagnosing and treating of the disease.

引用

页码：2453 / 2461

页数：9

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