Structural Activity Relationship based Medicinal Perspectives of Pyrimidine Derivatives as Anti-Alzheimer's Agents: A Comprehensive Review

被引：18

作者：

Das, Subham ^{[1
]}

Akbar, Saleem ^{[2
]}

Ahmed, Bahar ^{[2
]}

Dewangan, Rikeshwar Prasad ^{[2
]}

Iqubal, Ashif ^{[3
]}

Pottoo, Faheem Hyder ^{[4
]}

Joseph, Alex ^{[1
]}

机构：

[1] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharmaceut Chem, Manipal 576104, Karnataka, India

[2] Jamia Hamdard, Dept Pharmaceut Chem, Sch Pharmaceut Educ & Res, New Delhi 110062, India

[3] Jamia Hamdard, Dept Pharmacol, Sch Pharmaceut Educ & Res, New Delhi 110062, India

[4] Imam Abdulrahman Bin Faisal Univ, Coll Clin Pharm, Dept Pharmacol, POB 1982, Dammam 31441, Saudi Arabia

来源：

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS | 2022年 / 21卷 / 10期

关键词：

Pyrimidine; anti-Alzheimer's drugs; medicinal chemistry; SAR; pharmacology; neurological disorder; ACETYLCHOLINESTERASE INHIBITORS; PYRIMIDINYLTHIOUREA DERIVATIVES; MULTIFUNCTIONAL AGENTS; MONOAMINE-OXIDASE; MOLECULAR DOCKING; BUTYRYLCHOLINESTERASE; DISEASE; TRIAZOLOPYRIMIDINE; ANALOGS; HYBRIDS;

D O I：

10.2174/1871527320666210804161400

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pyrimidine is an aromatic and heterocyclic organic compound containing a 6-membered ring consisting of four carbon and two nitrogen atoms on alternative positions. Pyrimidine scaffolds described their existence in the medicinal chemist's cause for their synthesizing practicability and nonpoisonous nature. However, the reason behind neurological disorders is still an open challenge for scientific research and development organizations. Efficacy voids are widespread before researchers, despite high throughput research in the field of anti-Alzheimer's drugs.Researchers have constantly investigated all the probabilities for restraining the unwanted adverse effects of the anti-Alzheimer's agents and are focusing more extensively to rehabilitate neurological disorders. The scientific literature on drug development has been an aspiration to medicinal chemists and other researchers to facilitate further research. Therefore, this review emphasizes the structure-activity relationship (SAR) based approach and the pharmacological advancements of pyrimidine moiety in the new era of therapeutics as anti-Alzheimer's agents.

引用

页码：926 / 939

页数：14

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