Theranostic applications of smart nanomedicines for tumor-targeted chemotherapy: a review

被引：13

作者：

Juthi, Ajkia Zaman ^{[1
]}

Aquib, Md ^{[2
]}

Farooq, Muhammad Asim ^{[2
]}

Ghayas, Sana ^{[3
]}

Khalid, Farah ^{[3
]}

Boafo, George Frimpong ^{[2
]}

Wande, Dickson Pius ^{[4
]}

Khan, Daulat Haleem ^{[5
]}

Bithi, Tasnim Zaman ^{[6
]}

Bavi, Rohit ^{[7
]}

Wang, Bo ^{[2
]}

机构：

[1] Univ Sci & Technol China, Sch Life Sci, Dept Biochem & Mol Biol, East Campus, Hefei 230000, Anhui, Peoples R China

[2] China Pharmaceut Univ, Sch Pharm, Dept Pharmaceut, Nanjing, Jiangsu, Peoples R China

[3] Dow Univ Hlth Sci, Dow Coll Pharm, Dept Pharmaceut Sci, Karachi, Pakistan

[4] Muhimbili Univ Hlth & Allied Sci, Dept Pharmaceut, POB 65013, Dar Es Salaam, Tanzania

[5] Lahore Coll Pharmaceut Sci, Dept Pharm, Lahore, Pakistan

[6] Fouad Al Khateeb Hosp, Dept Med, Coxs Bazar, Bangladesh

[7] China Pharmaceut Univ, Sch Engn, Dept Biomed Engn, State Key Lab Nat Med, 24 Tongjia Xiang, Nanjing 210009, Gulou District, Peoples R China

来源：

ENVIRONMENTAL CHEMISTRY LETTERS | 2020年 / 18卷 / 05期

关键词：

Cancer therapy; Nanomedicines; Theranostic; Tumor targeting; MESOPOROUS SILICA NANOPARTICLES; RESPONSIVE DRUG-RELEASE; FOLATE RECEPTOR-ALPHA; ENHANCED PERMEABILITY; CELLULAR UPTAKE; BREAST-CANCER; CO-DELIVERY; MATRIX METALLOPROTEINASES; POLYMERIC MICELLES; PEPTIDE;

D O I：

10.1007/s10311-020-01031-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cancer is the result of disturbed cell functions. Cancer is induced by the accumulation of many genetic and epigenetic changes within the cell, expressed in the accumulation of chromosomal or molecular aberrations, which then leads to genetic instability. Chemotherapy is a major option to treat cancer, yet classical treatments induce toxic effects. Alternatively, cancer nanomedicines with tumor-targeted properties are very promising for improved safety and efficacy. Nanomedicines are sub-micrometer formulations designed to improve the biodistribution of anticancer drugs, resulting in modified toxicity, less off-target localization, enhanced efficacy and improved accumulation at the target site. For designing a targeted nanodrug system, the pathophysiological characteristics of tumors should be studied. This article explains how to make smart nanomedicines based on tumor-associated pathological features. Advantages include selective cell uptake, better drug release, increased therapeutic efficiency, receptor-mediated cell endocytosis, enhanced permeability and retention, and reduced systemic effects.

引用

页码：1509 / 1527

页数：19

共 167 条

[1] Antibody-drug conjugates (ADCs) for cancer therapy: Strategies, challenges, and successes [J].