Is there a role for immune and anti-inflammatory therapy in type 2 diabetes?

被引：0

作者：

Sathyapalan, T. ^{[1
]}

Atkin, S. L. ^{[1
]}

机构：

[1] Hull York Med Sch, Unit Endocrinol & Metab, Kingston Upon Hull, N Humberside, England

来源：

MINERVA ENDOCRINOLOGICA | 2011年 / 36卷 / 02期

关键词：

Inflammation; Diabetes mellitus; type; 2; Cytokines; Adipokines; C-REACTIVE PROTEIN; ENDOPLASMIC-RETICULUM STRESS; IL-1 RECEPTOR ANTAGONIST; BETA-CELL DYSFUNCTION; NECROSIS-FACTOR-ALPHA; MONOCYTE CHEMOATTRACTANT PROTEIN-1; ACTIVATED SIGNALING PATHWAYS; INDUCED INSULIN-RESISTANCE; NF-KAPPA-B; RHEUMATOID-ARTHRITIS;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is a growing body of evidence to suggest that type 2 diabetes is associated with a generalised activation of the innate immune system, in which there is a chronic low-grade inflammation. Further evidence for roles of inflammation in type 2 diabetes comes from clinical studies using either anti-inflammatory approaches or biological agents that target specific proinflammatory cytokine pathways to improve parameters of glucose control especially with IL-1 beta (Interleukin 1 beta) antagonism and salsalate (non-acetylated prodrug of salicylate) treatment. In this review, recent evidence implicating the pathological involvement of the immune system in type 2 diabetes is examined, together with the role of potential treatment modalities targeting the immune system in the management of type 2 diabetes.

引用

页码：147 / 156

页数：10

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