ACQ-to-AIE Transformation: Tuning Molecular Packing by Regioisomerization for Two-Photon NIR Bioimaging

被引：163

作者：

Li, Yuanyuan ^{[1
,7
]}

Liu, Shunjie ^{[1
]}

Ni, Huwei ^{[3
]}

Zhang, Haoke ^{[1
]}

Zhang, Hequn ^{[3
,4
]}

Chuah, Clarence ^{[1
]}

Ma, Chao ^{[5
]}

Wong, Kam Sing ^{[5
]}

Lam, Jacky W. Y. ^{[1
]}

Kwok, Ryan T. K. ^{[1
,7
]}

Qian, Jun ^{[3
]}

Lu, Xuefeng ^{[2
]}

Tang, Ben Zhong ^{[1
,6
,7
]}

机构：

[1] Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Dept Chem,Hong Kong Branch,Inst Adv Study, State Key Lab Mol Neurosci,Dept Chem & Biol Engn, Clear Water Bay, Hong Kong, Peoples R China

[2] Fudan Univ, Dept Mat Sci, Shanghai 200438, Peoples R China

[3] Zhejiang Univ, Coll Opt Sci & Engn, State Key Lab Modern Opt Instrumentat, Ctr Opt & Electromagnet Res, Hangzhou 310058, Peoples R China

[4] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Interdisciplinary Inst Neurosci & Technol ZIINT, Hangzhou 310020, Peoples R China

[5] Hong Kong Univ Sci & Technol, Dept Phys, Kowloon, Clear Water Bay, Hong Kong, Peoples R China

[6] South China Univ Technol, Ctr Aggregat Induced Emiss, SCUT HKUST Joint Res Inst, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Peoples R China

[7] HKUST Shenzhen Res Inst, 9 Yuexing 1st RD,Hitech Pk, Shenzhen 518057, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2020年 / 59卷 / 31期

基金：

美国国家科学基金会; 中国国家自然科学基金;

关键词：

ACQ-to-AIE transformation; aggregation-induced emission; cross packing; regioisomerization; two-photon imaging; AGGREGATION-INDUCED EMISSION; INTRAMOLECULAR CHARGE-TRANSFER; SOLID-STATE FLUORESCENCE; ABSORPTION; RED; STRATEGIES; DESIGN; PROBE;

D O I：

10.1002/anie.202005785

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The traditional design strategies for highly bright solid-state luminescent materials rely on weakening the intermolecular pi-pi interactions, which may limit diversity when developing new materials. Herein, we propose a strategy of tuning the molecular packing mode by regioisomerization to regulate the solid-state fluorescence. TBP-e-TPA with a molecular rotor in the end position of a planar core adopts a long-range cofacial packing mode, which in the solid state is almost non-emissive. By shifting molecular rotors to the bay position, the resultant TBP-b-TPA possesses a discrete cross packing mode, giving a quantum yield of 15.6 +/- 0.2 %. These results demonstrate the relationship between the solid-state fluorescence efficiency and the molecule's packing mode. Thanks to the good photophysical properties, TBP-b-TPA nanoparticles were used for two-photon deep brain imaging. This molecular design philosophy provides a new way of designing highly bright solid-state fluorophores.

引用

页码：12822 / 12826

页数：5

共 53 条

[11] Two-photon AIE bio-probe with large Stokes shift for specific imaging of lipid droplets [J].

Jiang, Meijuan ;

Gu, Xinggui ;

Lam, Jacky W. Y. ;

Zhang, Yilin ;

Kwok, Ryan T. K. ;

Wong, Kam Sing ;

Tang, Ben Zhong .

CHEMICAL SCIENCE, 2017, 8 (08) :5440-5446

[12] Molecular Packing: Another Key Point for the Performance o Organic and Polymeric Optoelectronic Materials [J].

Li, Qianqian ;

Li, Zhen .

ACCOUNTS OF CHEMICAL RESEARCH, 2020, 53 (04) :962-973

[13] Miracles of molecular uniting [J].

Li, Qianqian ;

Li, Zhen .

SCIENCE CHINA-MATERIALS, 2020, 63 (02) :177-184

[14] The Strong Light-Emission Materials in the Aggregated State: What Happens from a Single Molecule to the Collective Group [J].

Li, Qianqian ;

Li, Zhen .

ADVANCED SCIENCE, 2017, 4 (07)

[15] Sparks fly when AIE meets with polymers [J].

Li, Yuanyuan ;

Liu, Shunjie ;

Han, Ting ;

Zhang, Haoke ;

Chuah, Clarence ;

Kwok, Ryan T. K. ;

Lam, Jacky W. Y. ;

Tang, Ben Zhong .

MATERIALS CHEMISTRY FRONTIERS, 2019, 3 (11) :2207-2220

[16] Rare copy number variants in over 100,000 European ancestry subjects reveal multiple disease associations [J].

Li, Yun Rose ;

Glessner, Joseph T. ;

Coe, Bradley P. ;

Li, Jian-jun ;

Mohebnasab, Maede ;

Chang, Xiao ;

Connolly, John ;

Kao, Charlly ;

Wei, Zhi ;

Bradfield, Jonathan ;

Kim, Cecilia ;

Hou, Cuiping ;

Khan, Munir ;

Mentch, Frank ;

Qiu, Haijun ;

Bakay, Marina ;

Cardinale, Christopher ;

Lemma, Maria ;

Abrams, Debra ;

Bridglall-Jhingoor, Andrew ;

Behr, Meckenzie ;

Harrison, Shanell ;

Otieno, George ;

Thomas, Alexandria ;

Wang, Fengxiang ;

Chiavacci, Rosetta ;

Wu, Lawrence ;

Hadley, Dexter ;

Goldmuntz, Elizabeth ;

Elia, Josephine ;

Maris, John ;

Grundmeier, Robert ;

Devoto, Marcella ;

Keating, Brendan ;

March, Michael ;

Pellagrino, Renata ;

Grant, Struan F. A. ;

Sleiman, Patrick M. A. ;

Li, Mingyao ;

Eichler, Evan E. ;

Hakonarson, Hakon .

NATURE COMMUNICATIONS, 2020, 11 (01)

[17] Rotations in Excited ICT States - Fluorescence and its Microenvironmental Sensitivity [J].

Liese, David ;

Haberhauer, Gebhard .

ISRAEL JOURNAL OF CHEMISTRY, 2018, 58 (08) :813-826

[18]

Liu S., 2018, ANGEW CHEM, V130, P6382, DOI 10.1002/ange.v130.2110.1002/ ange.201803268

[19] Constitutional Isomerization Enables Bright NIR-II AIEgen for Brain-Inflammation Imaging [J].

Liu, Shunjie ;

Chen, Chao ;

Li, Yuanyuan ;

Zhang, Haoke ;

Liu, Junkai ;

Wang, Ran ;

Wong, Sherman T. H. ;

Lam, Jacky W. Y. ;

Ding, Dan ;

Tang, Ben Zhong .

ADVANCED FUNCTIONAL MATERIALS, 2020, 30 (07)

[20] Molecular Motion in the Solid State [J].

Liu, Shunjie ;

Li, Yuanyuan ;

Zhang, Haoke ;

Zhao, Zheng ;

Lu, Xuefeng ;

Lam, Jacky W. Y. ;

Tang, Ben Zhong .

ACS MATERIALS LETTERS, 2019, 1 (04) :425-+

← 1 2 3 4 5 6 →