ACQ-to-AIE Transformation: Tuning Molecular Packing by Regioisomerization for Two-Photon NIR Bioimaging

被引：163

作者：

Li, Yuanyuan ^{[1
,7
]}

Liu, Shunjie ^{[1
]}

Ni, Huwei ^{[3
]}

Zhang, Haoke ^{[1
]}

Zhang, Hequn ^{[3
,4
]}

Chuah, Clarence ^{[1
]}

Ma, Chao ^{[5
]}

Wong, Kam Sing ^{[5
]}

Lam, Jacky W. Y. ^{[1
]}

Kwok, Ryan T. K. ^{[1
,7
]}

Qian, Jun ^{[3
]}

Lu, Xuefeng ^{[2
]}

Tang, Ben Zhong ^{[1
,6
,7
]}

机构：

[1] Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Dept Chem,Hong Kong Branch,Inst Adv Study, State Key Lab Mol Neurosci,Dept Chem & Biol Engn, Clear Water Bay, Hong Kong, Peoples R China

[2] Fudan Univ, Dept Mat Sci, Shanghai 200438, Peoples R China

[3] Zhejiang Univ, Coll Opt Sci & Engn, State Key Lab Modern Opt Instrumentat, Ctr Opt & Electromagnet Res, Hangzhou 310058, Peoples R China

[4] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Interdisciplinary Inst Neurosci & Technol ZIINT, Hangzhou 310020, Peoples R China

[5] Hong Kong Univ Sci & Technol, Dept Phys, Kowloon, Clear Water Bay, Hong Kong, Peoples R China

[6] South China Univ Technol, Ctr Aggregat Induced Emiss, SCUT HKUST Joint Res Inst, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Peoples R China

[7] HKUST Shenzhen Res Inst, 9 Yuexing 1st RD,Hitech Pk, Shenzhen 518057, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2020年 / 59卷 / 31期

基金：

美国国家科学基金会; 中国国家自然科学基金;

关键词：

ACQ-to-AIE transformation; aggregation-induced emission; cross packing; regioisomerization; two-photon imaging; AGGREGATION-INDUCED EMISSION; INTRAMOLECULAR CHARGE-TRANSFER; SOLID-STATE FLUORESCENCE; ABSORPTION; RED; STRATEGIES; DESIGN; PROBE;

D O I：

10.1002/anie.202005785

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The traditional design strategies for highly bright solid-state luminescent materials rely on weakening the intermolecular pi-pi interactions, which may limit diversity when developing new materials. Herein, we propose a strategy of tuning the molecular packing mode by regioisomerization to regulate the solid-state fluorescence. TBP-e-TPA with a molecular rotor in the end position of a planar core adopts a long-range cofacial packing mode, which in the solid state is almost non-emissive. By shifting molecular rotors to the bay position, the resultant TBP-b-TPA possesses a discrete cross packing mode, giving a quantum yield of 15.6 +/- 0.2 %. These results demonstrate the relationship between the solid-state fluorescence efficiency and the molecule's packing mode. Thanks to the good photophysical properties, TBP-b-TPA nanoparticles were used for two-photon deep brain imaging. This molecular design philosophy provides a new way of designing highly bright solid-state fluorophores.

引用

页码：12822 / 12826

页数：5

共 53 条

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