The prognostic role of preoperative serum albumin/globulin ratio in patients with non-metastatic renal cell carcinoma undergoing partial or radical nephrectomy

被引：20

作者：

Chung, Jae-Wook ^{[1
]}

Park, Dong Jin ^{[1
]}

Chun, So Young ^{[1
]}

Choi, Seock Hwan ^{[1
]}

Lee, Jun Nyung ^{[1
]}

Kim, Bum Soo ^{[1
]}

Kim, Hyun Tae ^{[1
]}

Kim, Tae-Hwan ^{[1
]}

Yoo, Eun Sang ^{[1
]}

Byun, Seok-Soo ^{[2
]}

Hwang, Eu Chang ^{[3
]}

Kang, Seok Ho ^{[4
]}

Hong, Sung-Hoo ^{[5
]}

Chung, Jinsoo ^{[6
]}

Kwak, Cheol ^{[7
]}

Kim, Yong- June ^{[8
]}

Ha, Yun-Sok ^{[1
]}

Kwon, Tae Gyun ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Sch Med, Chilgok Hosp, Dept Urol, 807 Hoguk Ro, Daegu, South Korea

[2] Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Urol, Seongnam, South Korea

[3] Chonnam Natl Univ, Dept Urol, Sch Med, Gwangju, Jeonnam, South Korea

[4] Korea Univ, Dept Urol, Sch Med, Seoul, South Korea

[5] Catholic Univ Korea, Dept Urol, Coll Med, Seoul, South Korea

[6] Natl Canc Ctr, Dept Urol, Goyang, South Korea

[7] Seoul Natl Univ, Dept Urol, Coll Med, Seoul, South Korea

[8] Chungbuk Natl Univ, Dept Urol, Coll Med, Cheongju, South Korea

来源：

SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

CORTICOSTEROID-BINDING GLOBULIN; PLASMA PROTEOME DATABASE; PRETREATMENT ALBUMIN; CURATIVE RESECTION; CANCER STATISTICS; BREAST-CANCER; INFLAMMATION; PROTEINS; SURVIVAL; PATHOPHYSIOLOGY;

D O I：

10.1038/s41598-020-68975-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This multi-institutional study sought to clarify the association between the preoperative serum albumin/globulin ratio (AGR) and the prognosis of renal cell carcinoma (RCC) in a large cohort. This study encompassed eight institutions and 2,970 non-metastatic RCC patients who underwent a radical or partial nephrectomy from the Korean RCC (KORCC) database. A low AGR (1,143 patients; 38.5%) was defined as a preoperative AGR of less than 1.47 and a high AGR (1,827 patients; 61.5%) was defined as that 1.47 or greater. In the low AGR group, older age, female gender, the incidence of symptom presentation when diagnosed, diabetes, and hypertension was higher than in the high AGR group. Patients with low AGRs showed more progressive tumor stages with higher Fuhrman nuclear grades (all P-values<0.05). Patients in the low AGR group had a significantly lower overall survival rate (OS) and recurrence-free survival rate (RFS) in the Kaplan-Meier curves (all P-values<0.05). AGR was an independent prognostic factor for predicting the OS and RFS in the multivariate analysis (all P-values<0.05). The preoperative AGR is approachable and economical to use clinically for estimating the prognosis of RCC patients treated with surgery.

引用

页数：10

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