Successful use of posaconazole to treat invasive cutaneous fungal infection in a liver transplant patient on sirolimus

被引：8

作者：

Dahlan, Randah ^{[1
]}

Patel, Ameen ^{[2
]}

Haider, Shariq ^{[3
]}

机构：

[1] McMaster Univ, Dept Internal Med, Hamilton, ON L8S 4L8, Canada

[2] Hamilton Hlth Sci, Div Gen Internal Med, Hamilton, ON, Canada

[3] Hamilton Hlth Sci, Div Infect Dis, Hamilton, ON, Canada

来源：

CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY | 2012年 / 23卷 / 02期

关键词：

Cutaneous fungal infections; Liver transplantation; Posaconazole; Sirolimus; ORAL POSACONAZOLE; DRUG-INTERACTIONS; VORICONAZOLE; PHARMACOKINETICS; HEALTHY;

D O I：

10.1155/2012/272197

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Fungi are an important and common cause of cutaneous infections affecting solid organ transplant recipients. These infections can represent a primary site of infection with the potential for dissemination, or a manifestation of metastatic infection. The high morbidity and mortality associated with these infections necessitates urgent therapy with antifungal drugs; however, the interaction between these drugs and immunosuppressive therapies can be a major limitation because of drug toxicity. A case of soft tissue infection of the toe caused by Fusarium chlamydosporum and Candida guilliermondii in a liver transplant patient on sirolimus, who was successfully treated with the new antifungal agent posaconazole, is described. The pharmacokinetic interactions of sirolimus and the new triazoles, and their impact on treatment choices are briefly discussed.

引用

页码：E44 / E47

页数：4

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