Aberrant resting-state connectivity of auditory, ventral attention/salience and default-mode networks in adults with attention deficit hyperactivity disorder

被引:3
|
作者
Blomberg, Rina [1 ,2 ,3 ]
Signoret, Carine [1 ,2 ,3 ]
Danielsson, Henrik [1 ,2 ,3 ]
Perini, Irene [4 ,5 ]
Roennberg, Jerker [1 ,2 ,3 ,5 ]
Capusan, Andrea Johansson [4 ,6 ]
机构
[1] Linkoping Univ, Dept Behav Sci & Learning, Linkoping, Sweden
[2] Linkoping Univ, Linnaeus Ctr HEAD, Linkoping, Sweden
[3] Linkoping Univ, Swedish Inst Disabil Res, Linkoping, Sweden
[4] Linkoping Univ, Dept Biomed & Clin Sci, Ctr Social & Affect Neuroscience, Linkoping, Sweden
[5] Linkoping Univ, Ctr Med Image Sci & Visualizat, Linkoping, Sweden
[6] Linkoping Univ, Dept Psychiat & Biomed & Clin Sci, Linkoping, Sweden
关键词
attention deficit hyperactivity disorder; adults; resting state; functional connectivity; default mode network; salience network; auditory network; MEDIAL PREFRONTAL CORTEX; FUNCTIONAL CONNECTIVITY; BRAIN NETWORKS; ADHD; SCALE; DEACTIVATION; CINGULATE; SYSTEMS; SAMPLE; TASK;
D O I
10.3389/fnins.2022.972730
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background Numerous resting-state studies on attention deficit hyperactivity disorder (ADHD) have reported aberrant functional connectivity (FC) between the default-mode network (DMN) and the ventral attention/salience network (VA/SN). This finding has commonly been interpreted as an index of poorer DMN regulation associated with symptoms of mind wandering in ADHD literature. However, a competing perspective suggests that dysfunctional organization of the DMN and VA/SN may additionally index increased sensitivity to the external environment. The goal of the current study was to test this latter perspective in relation to auditory distraction by investigating whether ADHD-adults exhibit aberrant FC between DMN, VA/SN, and auditory networks. Methods Twelve minutes of resting-state fMRI data was collected from two adult groups: ADHD (n = 17) and controls (n = 17); from which the FC between predefined regions comprising the DMN, VA/SN, and auditory networks were analyzed. Results A weaker anticorrelation between the VA/SN and DMN was observed in ADHD. DMN and VA/SN hubs also exhibited aberrant FC with the auditory network in ADHD. Additionally, participants who displayed a stronger anticorrelation between the VA/SN and auditory network at rest, also performed better on a cognitively demanding behavioral task that involved ignoring a distracting auditory stimulus. Conclusion Results are consistent with the hypothesis that auditory distraction in ADHD is linked to aberrant interactions between DMN, VA/SN, and auditory systems. Our findings support models that implicate dysfunctional organization of the DMN and VA/SN in the disorder and encourage more research into sensory interactions with these major networks.
引用
收藏
页数:12
相关论文
共 50 条
  • [1] Altered intrinsic organisation of brain networks implicated in attentional processes in adult attention-deficit/hyperactivity disorder: a resting-state study of attention, default mode and salience network connectivity
    Sidlauskaite, Justina
    Sonuga-Barke, Edmund
    Roeyers, Herbert
    Wiersema, Jan R.
    EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2016, 266 (04) : 349 - 357
  • [2] Altered intrinsic organisation of brain networks implicated in attentional processes in adult attention-deficit/hyperactivity disorder: a resting-state study of attention, default mode and salience network connectivity
    Justina Sidlauskaite
    Edmund Sonuga-Barke
    Herbert Roeyers
    Jan R. Wiersema
    European Archives of Psychiatry and Clinical Neuroscience, 2016, 266 : 349 - 357
  • [3] Resting-State Functional Connectivity in Children with Primary Bipolar Disorder or Attention Deficit/Hyperactivity Disorder
    Puzia, Megan E.
    Lurie, Daniel L.
    Cushman, Grace K.
    Wegbreit, Ezra
    Weissman, Alexandra B.
    Kim, Kerri L.
    Castellanos, F. Xavier
    Milham, Michael P.
    Dickstein, Daniel P.
    BIOLOGICAL PSYCHIATRY, 2014, 75 (09) : 90S - 91S
  • [4] L-Cystine is associated with the dysconnectivity of the default-mode network and salience network in attention-deficit/hyperactivity disorder
    Wang, Liang-Jen
    Lin, Liang-Chun
    Lee, Sheng-Yu
    Wu, Chih-Ching
    Chou, Wen-Jiun
    Hsu, Chia-Fen
    Tseng, Huai-Hsuan
    Lin, Wei-Che
    PSYCHONEUROENDOCRINOLOGY, 2021, 125
  • [5] A Longitudinal Study of Resting-State Connectivity and Response to Psychostimulant Treatment in Attention/Deficit Hyperactivity Disorder
    Norman, Luke
    Sudre, Gustavo
    Bouyssi-Kobar, Marine
    Sharp, Wendy
    Shaw, Philip
    NEUROPSYCHOPHARMACOLOGY, 2020, 45 (SUPPL 1) : 290 - 291
  • [6] Resting-state connectivity and modulated somatomotor and default-mode networks in Huntington disease
    Sanchez-Castaneda, Cristina
    de Pasquale, Francesco
    Caravasso, Chiara Falletta
    Marano, Massimo
    Maffi, Sabrina
    Migliore, Simone
    Sabatini, Umberto
    Squitieri, Ferdinando
    CNS NEUROSCIENCE & THERAPEUTICS, 2017, 23 (06) : 488 - 497
  • [7] Aberrant Effective Connectivity of the Ventral Putamen in Boys With Attention-Deficit/Hyperactivity Disorder
    Lan, Zhihui
    Sun, Yunkai
    Zhao, Lei
    Xiao, Yang
    Kuai, Changxiao
    Xue, Shao-Wei
    PSYCHIATRY INVESTIGATION, 2021, 18 (08) : 763 - 769
  • [8] Dynamic functional connectivity changes of resting-state brain network in attention-deficit/hyperactivity disorder
    Zhu, Zhihao
    Wang, Hongwei
    Bi, Hui
    Lv, Jidong
    Zhang, Xiaotong
    Wang, Suhong
    Zou, Ling
    BEHAVIOURAL BRAIN RESEARCH, 2023, 437
  • [9] The Restless Brain: Attention-Deficit Hyperactivity Disorder, Resting-State Functional Connectivity, and Intrasubject Variability
    Castellanos, F. Xavier
    Kelly, Clare
    Milham, Michael P.
    CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2009, 54 (10): : 665 - 672
  • [10] Resting state dynamic functional connectivity in children with attention deficit/hyperactivity disorder
    Ahmadi, Maliheh
    Kazemi, Kamran
    Kuc, Katarzyna
    Cybulska-Klosowicz, Anita
    Helfroush, Mohammad Sadegh
    Aarabi, Ardalan
    JOURNAL OF NEURAL ENGINEERING, 2021, 18 (04)