Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells

被引：27
|
作者：
Chae, Hee-Sung [2 ]
Chin, Young-Won [1 ]
机构：
[1] Dongguk Univ Seoul, Coll Pharm, Seoul, South Korea
[2] Korea Res Inst Biosci & Biotechnol, Immune Modulator Res Ctr, Biotherapeut Res Inst, Seoul, South Korea
来源：
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 2012年 / 34卷 / 02期
关键词：
Lambertianic acid; bone marrow-derived mast cell; allergy; IL-6; PGD(2); LTC4; beta-hexosaminidase; COX-2; CYCLOOXYGENASE; INHIBITORS; ACTIVATION; PINUSOLIDE; CALCIUM;
D O I：
10.3109/08923973.2011.600763
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Lambertianic acid is a bioactive diterpene found in the leaves of Thuja orientalis. Its effect on the bone marrow-derived mast cell (BMMC) mediated allergy and inflammation mechanism remains unknown. In this study, lambertianic acid was evaluated for its effect on the allergic mediators, including prostaglandin D-2 (PGD(2)), leukotriene C-4 (LTC4), beta-hexosaminidase (beta-Hex) and cyclooxygenase-2 (COX-2) protein, in phorbol 12-myristate 13-acetate (PMA) plus calcimycin-stimulated BMMCs. The results revealed that lambertianic acid inhibited the production of interleukin-6 (IL-6), PGD(2) and LTC4, the expression of COX-2 and the degranulation of beta-hexosaminidase in the PMA plus calcimycin-induced BMMCs. Taken together, these findings implied that lambertianic acid may possess the potential in the treatment of allergy.
引用
收藏
页码：250 / 255
页数：6
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