Stem Cell-Derived Extracellular Vesicles as Immunomodulatory Therapeutics

被引：115
作者：
Seo, Yoojin [1 ]
Kim, Hyung-Sik [1 ,2 ]
Hong, In-Sun [3 ,4 ]
机构：
[1] Pusan Natl Univ, Inst Translat Dent Sci, Sch Dent, Yangsan 50612, South Korea
[2] Pusan Natl Univ, Sch Dent, Dept Life Sci Dent, Yangsan 50612, South Korea
[3] Gachon Univ, Lee Gil Ya Canc & Diabet Inst, Lab Stem Cell Res, Incheon 21999, South Korea
[4] Gachon Univ, Sch Med, Dept Mol Med, Incheon 21999, South Korea
来源：
STEM CELLS INTERNATIONAL | 2019年 / 2019卷
基金：
新加坡国家研究基金会;
关键词：
MESENCHYMAL STROMAL CELLS; ALLERGIC AIRWAY INFLAMMATION; VERSUS-HOST-DISEASE; BONE-MARROW; DENDRITIC CELLS; IMMUNE-RESPONSES; MOUSE MODEL; T-CELLS; EXOSOMES; INHIBIT;
D O I：
10.1155/2019/5126156
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Mesenchymal stem cells (MSCs) have been reported to possess regulatory functions on immune cells which make them alternative therapeutics for the treatment of inflammatory and autoimmune diseases. The interaction between MSCs and immune cells through paracrine factors might be crucial for these immunomodulatory effects of MSCs. Extracellular vesicles (EVs) are defined as bilayer membrane structures including exosomes and microvesicles which contain bioactive paracrine molecules affecting the characteristics of target cells. Recently, several studies have revealed that EVs derived from MSCs (MSC-EVs) can reproduce similar therapeutic impacts of parent MSCs; MSC-EVs could regulate proliferation, maturation, polarization, and migration of various immune effector cells and modulate the immune microenvironment depending on the context by delivering inflammatory cytokines, transcription factors, and microRNAs. Therefore, MSC-EVs can be applied as novel and promising tools for the treatment of immune-related disorders to overcome the limitations of conventional cell therapy regarding efficacy and toxicity issues. In this review, we will discuss current insights regarding the major outcomes in the evaluation of MSC-EV function against inflammatory disease models, as well as immune cells.
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页数：10
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