Evaluation of osteoarthritis induced by treadmill-running exercise using the modified Mankin and the new OARSI assessment system

被引：31

作者：

Lee, Yun Jong ^{[1
]}

Park, Ji Ah ^{[1
]}

Yang, Sei Hoon ^{[2
]}

Kim, Kwang Yong ^{[1
]}

Kim, Byoung Kwon ^{[3
]}

Lee, Eun Young ^{[1
]}

Lee, Eun Bong ^{[1
]}

Seo, Jeong-Wook ^{[3
]}

Echtermeyer, Frank ^{[4
]}

Pap, Thomas ^{[5
]}

Song, Yeong Wook ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Med, Dept Internal Med, Clin Res Inst, Seoul 110744, South Korea

[2] Wonkwang Univ, Dept Internal Med, Sch Med, Iksan 570749, Jeonbuk, South Korea

[3] Seoul Natl Univ, Coll Med, Dept Pathol, Clin Res Inst, Seoul 110744, South Korea

[4] Hannover Med Sch, Dept Anesthesiol & Intens Care Med, D-3000 Hannover, Germany

[5] Univ Hosp Munster, Dept Orthoped, Div Mol Med Musculoskeletal Tissue, D-48149 Munster, Germany

来源：

RHEUMATOLOGY INTERNATIONAL | 2011年 / 31卷 / 12期

关键词：

Osteoarthritis; Treadmill; OARSI osteoarthritis score; Modified Mankin score; Wistar rats; HISTOLOGIC/HISTOCHEMICAL GRADING SYSTEM; ARTICULAR-CARTILAGE; REPRODUCIBILITY; HISTOPATHOLOGY; RELIABILITY; DEGRADATION; APOPTOSIS; VALIDITY; JOINTS; MODELS;

D O I：

10.1007/s00296-010-1520-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To apply the Osteoarthritis Research Society International (OARSI) assessment system to an osteoarthritis model, 44 Wistar rats were randomized into treadmill-running exercise or control group. At 6, 8, and 10 weeks, medial knee joints were histopathologically evaluated, and aggrecan neoepitope and TUNEL staining were performed. Cartilage changes in exercise group were histopathologically and histochemically compatible with early OA. Total modified Mankin system (MMS) scores were significantly higher at all time points (each P a parts per thousand currency sign 0.01) in exercise than in control group. However, only tibial OARSI scores of runners were higher at 10 weeks (P < 0.05), although OARSI scores were found to be significantly correlated with MMS scores. Both total MMS (Spearman's coefficient rho = 0.786) and OARSI scores (rho = 0.443 for femoral; rho = 0.604 for tibial) were significantly associated with the exercise duration. In conclusion, the OARSI system may not be sensitive to early OA changes induced by treadmill exercise.

引用

页码：1571 / 1576

页数：6

共 3 条

[1] Evaluation of osteoarthritis induced by treadmill-running exercise using the modified Mankin and the new OARSI assessment system
Yun Jong Lee
Ji Ah Park
Sei Hoon Yang
Kwang Yong Kim
Byoung Kwon Kim
Eun Young Lee
Eun Bong Lee
Jeong-Wook Seo
Frank Echtermeyer
Thomas Pap
Yeong Wook Song
Rheumatology International, 2011, 31 : 1571 - 1576
[2] OARSI Osteoarthritis Cartilage Histopathology Assessment System: A Biomechanical Evaluation in the Human Knee
Waldstein, Wenzel
Perino, Giorgio
Gilbert, Susannah L.
Maher, Suzanne A.
Windhager, Reinhard
Boettner, Friedrich
JOURNAL OF ORTHOPAEDIC RESEARCH, 2016, 34 (01) : 135 - 140
[3] Reliability, reproducibility and variability of the traditional Histologic/Histochemical Grading System vs the new OARSI Osteoarthritis Cartilage Histopathology Assessment System
Custers, R. J. H.
Creemers, L. B.
Verbout, A. J.
van Rijen, M. H. P.
Dhert, W. J. A.
Saris, D. B. F.
OSTEOARTHRITIS AND CARTILAGE, 2007, 15 (11) : 1241 - 1248

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