Pneumocystis jirovecii Pneumonia in Three Patients With Breast Cancer Receiving Neoadjuvant Dose-Dense Chemotherapy

被引：3

作者：

Shiiba, Ritsuya ^{[1
]}

Himeji, Daisuke ^{[1
]}

Matsumoto, Ryoichi ^{[1
]}

Tanaka, Gen-ichi ^{[1
]}

Otomo, Naoki ^{[2
]}

机构：

[1] Miyazaki Prefectural Miyazaki Hosp, Dept Internal Med, Miyazaki, Japan

[2] Miyazaki Prefectural Miyazaki Hosp, Dept Surg, Miyazaki, Japan

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2022年 / 14卷 / 02期

关键词：

pneumocystis jirovecii pneumonia; lymphocytopenia; neoadjuvant chemotherapy; dose-dense chemotherapy; breast cancer; SURGICAL ADJUVANT BREAST; CARINII-PNEUMONIA; RANDOMIZED-TRIAL; RISK; METAANALYSIS; TAMOXIFEN; DIAGNOSIS; TUMORS;

D O I：

10.7759/cureus.21812

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report three cases of Pneumocystis jirovecii pneumonia (PJP) during dose-dense neoadjuvant chemotherapy for breast cancer. All patients presented with symptoms (e.g., fever), and computed tomography showed diffuse ground-glass shadows. Bronchoalveolar lavage was performed, and the diagnosis was confirmed by polymerase chain reaction for Pneumocystis jirovecii. All patients had completed three or four courses of dose-dense epirubicin-cyclophosphamide chemotherapy and received prednisolone for preventing chemo-induced nausea and vomiting. Moreover, lymphocytopenia was observed in all patients. Since the onset of PJP in preoperative neoadjuvant chemotherapy can be life- threatening and leads to delayed surgery, careful consideration of prophylaxis for PJP is required.

引用

页数：7

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