Pomalidomide, cyclophosphamide, and dexamethasone for relapsed multiple myeloma

被引:54
作者
Garderet, Laurent [1 ,2 ,3 ]
Kuhnowski, Frederique [4 ]
Berge, Benoit [5 ]
Roussel, Murielle [6 ]
Escoffre-Barbe, Martine [7 ]
Lafon, Ingrid [8 ]
Facon, Thierry [9 ]
Leleu, Xavier [9 ]
Karlin, Lionel [10 ]
Perrot, Aurore [11 ]
Moreau, Philippe [12 ]
Marit, Gerald [13 ]
Stoppa, Anne-Marie [14 ]
Royer, Bruno [15 ]
Chaleteix, Carine [16 ]
Tiab, Mourad [17 ]
Araujo, Carla [18 ]
Lenain, Pascal [19 ]
Macro, Margaret [20 ]
Voog, Eric [21 ]
Benboubker, Lofti [22 ]
Allangba, Olivier [23 ]
Jourdan, Eric [24 ]
Orsini-Piocelle, Frederique [25 ]
Brechignac, Sabine [26 ]
Eveillard, Jean-Richard [27 ]
Belhadj, Karim [28 ]
Wetterwald, Marc [29 ]
Pegourie, Brigitte [30 ]
Jaccard, Arnaud [31 ]
Eisenmann, Jean-Claude [32 ]
Glaisner, Sylvie [33 ]
Mohty, Mohamad [1 ,2 ,3 ]
Hulin, Cyrille [13 ]
Avet-Loiseau, Herve [34 ]
Mathiot, Claire [4 ]
Attal, Michel [6 ]
机构
[1] INSERM, Proliferat & Differentiat Stem Cells, UMR S 938, Paris, France
[2] Hop St Antoine, AP HP, Dept Hematol & Therapie Cellulaire, Paris, France
[3] Sorbonne Univ, Paris, France
[4] Inst Curie, Paris, France
[5] Euraxi, Paris, France
[6] Inst Univ Canc Toulouse Oncopole, Ctr Hosp Univ, Toulouse, France
[7] Ctr Hosp Univ, Rennes, France
[8] Ctr Hosp Univ, Dijon, France
[9] Ctr Hosp Reg Univ Lille, Hop Claude Huriez, Malad Sang, Lille, France
[10] Hosp Civils Lyon, Pierre Benite, France
[11] Ctr Hosp Univ, Vandoeuvre Les Nancy, France
[12] Ctr Hosp Univ Hotel Dieu, Nantes, France
[13] Ctr Hosp Univ, Bordeaux, France
[14] Inst Paoli Calmettes, Dept Hematol, Marseille, France
[15] Ctr Hosp Univ, Amiens, France
[16] Ctr Hosp Univ, Clermont Ferrand, France
[17] Hop La Roche Sur Yon, La Roche Sur Yon, France
[18] Ctr Hosp Cote Basque, Bayonne, France
[19] Ctr Henri Becquerel, Rouen, France
[20] Ctr Hosp Univ, Caen, France
[21] Ctr Hosp La Mans, Le Mans, France
[22] Hop Bretonneau, Ctr Hosp Univ, Tours, France
[23] Ctr Hosp St Brieuc, St Brieuc, France
[24] Ctr Hosp Univ, Nimes, France
[25] Ctr Hosp Reg Annecy, Pringy, France
[26] Hop Avicenne, Bobigny, France
[27] Hop Morvan, Brest, France
[28] Ctr Hosp Univ Henri Mondor, Creteil, France
[29] Ctr Hosp Gen, Dunkerque, France
[30] Ctr Hosp Reg & Univ, Grenoble, France
[31] Ctr Hosp Univ, Limoges, France
[32] Hop Emile Muller, Mulhouse, France
[33] Hop Rene Huguenin, St Cloud, France
[34] Hop Rangueil, Toulouse, France
关键词
LOW-DOSE DEXAMETHASONE; IMMUNOMODULATORY DRUGS; OPEN-LABEL; LENALIDOMIDE; BORTEZOMIB; CARFILZOMIB; DARATUMUMAB; PREDNISONE; THERAPY;
D O I
10.1182/blood-2018-07-863829
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
It is important to have an effective therapy for patients with multiple myeloma (MM) at first relapse, particularly if an autologous stem cell transplant (ASCT) is considered at this stage. This multicenter, phase 2 trial evaluated the efficacy and safety of weekly oral pomalidomide-cyclophosphamide-dexamethasone (PCD) in patients with MM in first relapse after treatment with lenalidomide-bortezomib-dexamethasone (RVD). All patients had received RVD as induction and consolidation therapy, plus lenalidomide maintenance for 1 year (arm A). Half had also received an ASCT after induction (arm B). At MM relapse, all patients received 4 oral cycles of pomalidomide 4 mg (days 1-21), cyclophosphamide 300 mg (days 1, 8, 15, and 22), and dexamethasone 40 mg (days 1-4 and days 15-18 of a 28-day cycle; PCD). Responding patients in arm A underwent ASCT and received 2 additional cycles of PCD, whereas those in arm B received 5 cycles of PCD. All patients received pomalidomide-dexamethasone maintenance until disease progression. Primary end point was partial remission or better after the initial 4 cycles of PCD. Responses were obtained in 82/97 (85%) patients evaluated: complete remission (n = 1; 1%), very good partial remission (n = 32; 33%), and partial remission (n = 49; 51%). Three patients (3%) had stable disease, and 6 (6%) had disease progression (6 response failures). Forty-five (94%) of the 48 patients in arm A underwent planned ASCT. PCD was effective therapy after first relapse with RVD. After 4 cycles, the rate of partial remission or better was 85%, and 94% of planned ASCTs were performed. Toxicity was mostly hematologic and manageable. This trial was registered at www.clinicaltrials.gov as #NCT02244125.
引用
收藏
页码:2555 / 2563
页数:9
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