Oral Immunotherapy in Children: Clinical Considerations and Practical Management

被引：4

作者：

Anderson, Brent ^{[1
]}

Wong, Lauren ^{[1
]}

Adlou, Bahman ^{[1
]}

Long, Andrew ^{[1
]}

Chinthrajah, R. Sharon ^{[1
]}

机构：

[1] Stanford Univ, Sean N Parker Ctr Allergy & Asthma Res, Stanford, CA 94305 USA

来源：

JOURNAL OF ASTHMA AND ALLERGY | 2021年 / 14卷

基金：

美国国家卫生研究院;

关键词：

food allergy; atopy; desensitization; tolerance; omalizumab; dupilumab; IgE; sustained unresponsiveness; DOUBLE-BLIND; SUSTAINED UNRESPONSIVENESS; FOOD ALLERGY; ANTI-IGE; OMALIZUMAB; PEANUT; DESENSITIZATION; RISK; RESPONSES; EFFICACY;

D O I：

10.2147/JAA.S282696

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Oral immunotherapy (OIT) in pediatric patients provides an alternative option to the current standard of care in food allergy, which is allergen avoidance and reactive treatment. Because patients are exposed to one or more food allergens during treatment, OIT is associated with adverse events and can be a cumbersome process for children, their caregivers, and clinicians. However, there have been an overwhelming number of studies that show high efficacy in both single-and multi-allergen OIT, and that quality of life is greatly improved for both patients and their families after undergoing immunotherapy. This review discusses clinical considerations for OIT in pediatrics, including efficacy and safety, practical management, and future directions of treatment.

引用

页码：1497 / 1510

页数：14

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