Mechanisms of genomic and non-genomic actions of carotenoids

被引：65

作者：

Elliott, R ^{[1
]}

机构：

[1] Inst Food Res, Inst Food Res, Norwich NR4 7UA, Norfolk, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2005年 / 1740卷 / 02期

关键词：

carotenoid; beta-carotene; vitamin A; gene expression; functional genomics; model system;

D O I：

10.1016/j.bbadis.2004.12.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carotenoids are highly bioactive dietary compounds that have the potential to have significant effects on human health. It is becoming increasingly clear that the various biological effects; that carotenoids exert could be driven via a number of different mechanisms. These include direct pro- and antioxidant effects, redox sensitive cell signalling, vitamin A signalling pathways and other as yet unidentified mechanisms. This article provides an overview of the known effects of carotenoids and discusses the use of model systems and functional genomic approaches further to elucidate their modes of action. (c) 2004 Elsevier B.V. All rights reserved.

引用

页码：147 / 154

页数：8

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