APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p

被引：398

作者：

Wang, Kun ^{[1
]}

Liu, Cui-Yun ^{[2
]}

Zhou, Lu-Yu ^{[1
]}

Wang, Jian-Xun ^{[1
]}

Wang, Man ^{[1
]}

Zhao, Bing ^{[1
]}

Zhao, Wen-Ke ^{[1
]}

Xu, Shi-Jun ^{[3
]}

Fan, Li-Hua ^{[2
]}

Zhang, Xiao-Jie ^{[2
]}

Feng, Chang ^{[2
]}

Wang, Chao-Qun ^{[1
]}

Zhao, Yan-Fang ^{[1
]}

Li, Pei-Feng ^{[1
]}

机构：

[1] Qingdao Univ, Coll Med, Inst Translat Med, Ctr Dev Cardiol, Qingdao 266021, Peoples R China

[2] Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China

[3] Capital Med Univ, Beijing Inst Heart Lung & Blood Vessel Dis, Anzen Hosp, Beijing 100029, Peoples R China

来源：

NATURE COMMUNICATIONS | 2015年 / 6卷

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

LONG NONCODING RNA; CELL-DEATH; MICRORNA; CONSERVATION; EXPRESSION; EVOLUTION; SEQUENCE; DISEASE; CANCER; HEART;

D O I：

10.1038/ncomms7779

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The abnormal autophagy is associated with a variety of cardiovascular diseases. Long noncoding RNAs (lncRNAs) are emerging as new factors in gene regulation, but how lncRNAs operate in the regulation of autophagy in the heart is unclear. Here we report that a long noncoding RNA, named autophagy promoting factor (APF), can regulate autophagic cell death by targeting miR-188-3p and ATG7. The results show that miR-188-3p suppresses autophagy and myocardial infarction by targeting ATG7. Further, we find that APF lncRNA regulates miR-188-3p, and thus affects ATG7 expression, autophagic cell death and myocardial infarction. Our present study reveals a novel regulating model of autophagic programme, which comprises APF, miR-188-3p and ATG7 in the heart. Modulation of their levels may serve as potential targets and diagnostic tools for novel therapeutic strategies of myocardial infarction and heart failure.

引用

页数：11

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