Non-enzymatic continuous glucose monitoring system

被引:1
作者
Moore, Sean [1 ]
You, Byoung Hee [1 ]
Kim, Namwon [2 ]
Park, Taehyun [3 ]
Song, In-Hyouk [1 ]
机构
[1] Texas State Univ San Marcos, Dept Engn Technol, San Marcos, TX 78666 USA
[2] Texas State Univ San Marcos, Ingram Sch Engn, San Marcos, TX 78666 USA
[3] Kyungnam Univ, Sch Mech Engn, Changwon Si, Gyeongsangnam D, South Korea
来源
MICRO & NANO LETTERS | 2018年 / 13卷 / 08期
关键词
biosensors; patient monitoring; biochemistry; electrochemical sensors; electrochemical electrodes; blood; biomedical electrodes; chemical sensors; biomedical measurement; bioelectric phenomena; glucose concentration; entire glucose range; continuous glucose monitoring method; nonenzymatic continuous glucose monitoring system; nonenzymatic glucose sensor; biosensor development; electric properties; fluids contents; electrode surface area; impedimetric response; real-time measurement; charge transfer resistance; frequency; 10; 0; kHz; resistance; 1038; kohm; 752; 688; ELECTRODE; NANOPARTICLES; SENSOR; GOLD; NANOCOMPOSITES; FABRICATION; SIO2;
D O I
10.1049/mnl.2017.0894
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
A prominent field of study in biosensor development is the study of electric properties which provide valuable insight into the fluids contents. In this research, a non-enzymatic glucose sensor is fabricated, characterised, and employed. The developed device determines the effects of electrode surface area on sensing efficacy, the effects of glucose concentration on impedimetric response, and a real-time measurement of glucose concentration. Deviations throughout the entire glucose range are detected as an inverse of the impedance in the cell due to the inverse relationship of glucose concentration and charge transfer resistance. The continuous monitoring of glucose is demonstrated by a rapid device response over two iterations of glucose concentration in ascending order: 50 mu M, 400 mu M, and 3.2 mM. At a sustained frequency of 10 kHz, the result shows a stable impedimetric response of 1038, 752, and 688 k, respectively. The validity of the device as a continuous glucose monitoring method is carried out by repeating the cycle and observing the response.
引用
收藏
页码:1079 / 1084
页数:6
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