Extracorporeal photopheresis for GVHD prophylaxis after reduced intensity conditioning allogeneic hematopoietic stem cell transplantation: a prospective multicenter phase 2 study

被引：20

作者：

Michallet, Mauricette ^{[1
]}

Sobh, Mohamad ^{[1
]}

Garban, Frederic ^{[2
]}

Bulabois, Claude Eric ^{[2
]}

Yakoub-Agha, Ibrahim ^{[3
]}

Coiteux, Valerie ^{[3
]}

Dulery, Remy ^{[3
]}

Rohrlich, Pierre-Simon ^{[4
]}

Legrand, Faezeh ^{[4
]}

Clement, Laurence ^{[5
]}

Praire, Aline ^{[1
]}

Detrait, Marie ^{[1
]}

Barraco, Fiorenza ^{[1
]}

Nicolini, Franck Emmanuel ^{[1
]}

Hequet, Olivier ^{[6
]}

机构：

[1] Ctr Hosp Lyon Sud, Hematol Dept 1G, Pierre Benite, France

[2] CHU Grenoble, Hematol Dept, Grenoble, France

[3] CHRU Lille, Hop Claude Huriez, Serv Malad Sang, Lille, France

[4] CHU Nice, Hematol Dept, Nice, France

[5] CHU Nancy, Nancy, France

[6] Ctr Hosp Lyon Sud, Blood Bank Ctr, Pierre Benite, France

来源：

LEUKEMIA & LYMPHOMA | 2018年 / 59卷 / 02期

关键词：

Extracorporeal photopheresis; GVHD; Allo-HSCT; VERSUS-HOST-DISEASE; ANTITHYMOCYTE GLOBULINS PRIOR; MARROW-TRANSPLANTATION; INTRAVENOUS BUSULFAN; PERIPHERAL-BLOOD; FREE SURVIVAL; T-CELLS; PHOTOCHEMOTHERAPY; REGIMEN; INDUCTION;

D O I：

10.1080/10428194.2017.1334120

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We performed a prospective multicenter phase 2 study to evaluate the safety and efficacy of prophylactic Extracorporeal Photopheresis (ECP) in adult patients with hematological malignancies early after RIC allo-HSCT on day 21 twice per week during the first two weeks and then once per week for the next four weeks for a total of eight ECP courses. A total of 20 patients were included; 10 were males, median age was 60 years. All patients engrafted, 17 (85%) received the total eight ECP courses. There were no adverse effects related to ECP. Seven patients developed acute graft-versus-host disease (GVHD), with 15% grade II cumulative incidence at day 100. The cumulative incidence of chronic GVHD at 2 years was 22%. The 2 years probability of overall survival (OS) and progression-free survival (PFS) were 84 and 74%, respectively. This study shows encouraging results with low acute and chronic GVHD incidence and no interference with graft-versus-leukemia (GVL) effect.

引用

页码：372 / 380

页数：9

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