Extracorporeal photopheresis for GVHD prophylaxis after reduced intensity conditioning allogeneic hematopoietic stem cell transplantation: a prospective multicenter phase 2 study

被引：20
|
作者：
Michallet, Mauricette [1 ]
Sobh, Mohamad [1 ]
Garban, Frederic [2 ]
Bulabois, Claude Eric [2 ]
Yakoub-Agha, Ibrahim [3 ]
Coiteux, Valerie [3 ]
Dulery, Remy [3 ]
Rohrlich, Pierre-Simon [4 ]
Legrand, Faezeh [4 ]
Clement, Laurence [5 ]
Praire, Aline [1 ]
Detrait, Marie [1 ]
Barraco, Fiorenza [1 ]
Nicolini, Franck Emmanuel [1 ]
Hequet, Olivier [6 ]
机构：
[1] Ctr Hosp Lyon Sud, Hematol Dept 1G, Pierre Benite, France
[2] CHU Grenoble, Hematol Dept, Grenoble, France
[3] CHRU Lille, Hop Claude Huriez, Serv Malad Sang, Lille, France
[4] CHU Nice, Hematol Dept, Nice, France
[5] CHU Nancy, Nancy, France
[6] Ctr Hosp Lyon Sud, Blood Bank Ctr, Pierre Benite, France
来源：
LEUKEMIA & LYMPHOMA | 2018年 / 59卷 / 02期
关键词：
Extracorporeal photopheresis; GVHD; Allo-HSCT; VERSUS-HOST-DISEASE; ANTITHYMOCYTE GLOBULINS PRIOR; MARROW-TRANSPLANTATION; INTRAVENOUS BUSULFAN; PERIPHERAL-BLOOD; FREE SURVIVAL; T-CELLS; PHOTOCHEMOTHERAPY; REGIMEN; INDUCTION;
D O I：
10.1080/10428194.2017.1334120
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We performed a prospective multicenter phase 2 study to evaluate the safety and efficacy of prophylactic Extracorporeal Photopheresis (ECP) in adult patients with hematological malignancies early after RIC allo-HSCT on day 21 twice per week during the first two weeks and then once per week for the next four weeks for a total of eight ECP courses. A total of 20 patients were included; 10 were males, median age was 60 years. All patients engrafted, 17 (85%) received the total eight ECP courses. There were no adverse effects related to ECP. Seven patients developed acute graft-versus-host disease (GVHD), with 15% grade II cumulative incidence at day 100. The cumulative incidence of chronic GVHD at 2 years was 22%. The 2 years probability of overall survival (OS) and progression-free survival (PFS) were 84 and 74%, respectively. This study shows encouraging results with low acute and chronic GVHD incidence and no interference with graft-versus-leukemia (GVL) effect.
引用
收藏
页码：372 / 380
页数：9
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