MPTP-induced Animal Model of Parkinson's Disease Dementia: There are Species Differences

被引：0

作者：

Ho, S. C. ^{[1
]}

Huang, G. J. ^{[1
]}

Lai, C. K. ^{[2
]}

Gu, S. L. ^{[2
]}

Hsieh, M. H. ^{[3
,4
]}

Ho, Y. J. ^{[1
]}

机构：

[1] Chung Shan Med Univ Hosp, Sch Psychol, Taichung, Taiwan

[2] Chung Shan Med Univ Hosp, Sch Med Lab & Biotehnol, Taichung, Taiwan

[3] Chung Shan Med Univ Hosp, Dept Psychiat, Taichung, Taiwan

[4] Chung Shan Med Univ, Sch Med, Taichung, Taiwan

来源：

XVII INTERNATIONAL CONGRESS OF NEUROPATHOLOGY (ICN) | 2010年

关键词：

WISTAR RATS; OBJECT RECOGNITION; NEUROINFLAMMATION; DEFICITS; MOUSE;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This study evaluated the differences in animal models of Parkinson's disease dementia (PDD) in rats and mice. MPTP was infused into the substantia nigra of male Wistar rats. Male C57BL/6 mice received intraperitoneal injection of MPTP. One day later, the animals were subjected to a battery of behavioral tests for measuring motor function in the rotarod or open field, anxiety level in the elevated plus-maze, learning and working memory in the T-maze or active avoidance test, and recognition in the object recognition test. MPTP lesion in rats caused deficits in motor, anxiety, recognition, and learning abilities. MPTP-treated mice showed only impairments in movement and recognition. These results provide evidence for taking species differences into account when MPTP-treated animals are used as models for PDD.

引用

页码：23 / 29

页数：7

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