Microbial transformation of cinobufagin by Syncephalastrum racemosum

被引：41
作者：
Ma, Xiao-chi [1 ,2 ]
Xin, Xiu-lan [1 ,3 ]
Liu, Ke-xin [2 ]
Han, Jian [1 ]
Guo, De-an [1 ]
机构：
[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimetr Drugs, Beijing 100083, Peoples R China
[2] Dalian Med Univ, Sch Pharmaceut Sci, Dalian 116027, Peoples R China
[3] Beijing Vocat Coll Elect Sci & Technol, Biotechnol Applicat Ctr, Beijing, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 07期
关键词：
D O I：
10.1021/np800210a
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Microbial transformation of a cytotoxic bufadienolide, cinobufagin (1), was performed by Syncephalastrum racemosum. The six metabolites obtained were identified as 7 beta-hydroxycinobufagin (2), 12 beta-hydroxycinobufagin (3), cinobufotalin (4), 5,12 beta-dihydroxycinobufagin (5), 4 beta, 11 alpha-dihydroxycinobufagin (6), and 4 beta, 12 alpha-dihydroxycinobufagin (7), respectively, on the basis of spectroscopic studies. Metabolites 2 and 5-7 were characterized as new compounds, and 2-7 proved to be cytotoxic against Bel-7402 human hepatoma cells.
引用
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页码：1268 / 1270
页数：3
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