Highly stereoselective synthesis of (Z)-1,2-dihaloalkenes by a Pd-catalyzed hydrohalogenation of alkynyl halides

被引：63

作者：

Zhu, Gangguo ^{[1
]}

Chen, Dongxu ^{[1
]}

Wang, Yuyi ^{[1
]}

Zheng, Renwei ^{[1
]}

机构：

[1] Zhejiang Normal Univ, Dept Chem, Jinhua 321004, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 46期

基金：

中国国家自然科学基金;

关键词：

ISOMER TETRASUBSTITUTED OLEFINS; CIS-STILBENOID HYDROCARBONS; CROSS-COUPLING REACTIONS; CARBON-PALLADIUM BOND; ORGANIC-SYNTHESIS; CONJUGATE ADDITION; IONIC LIQUIDS; CYCLIZATION; ALKENES; PROTONOLYSIS;

D O I：

10.1039/c2cc31553j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An unprecedented Pd-catalyzed hydrohalogenation of alkynyl halides for the regio- and stereoselective synthesis of (Z)-1,2-dihaloalkenes has been realized using [(allyl)PdCl](2) as the catalyst and cis, cis-1,5-cyclooctadiene as the ligand. The advantages of this protocol are well illustrated by the assembly of trisubstituted (Z)-enynes and multifunctional benzenes via iterative cross-coupling reactions or tandem Diels-Alder-aromatization reactions, respectively.

引用

页码：5796 / 5798

页数：3

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