Science to Practice: The Changing Face of Local Tumor Therapies-Do We Have to Think Systemically When Treating Cancer Locally?

被引：9

作者：

Chapiro, Julius ^{[1
]}

Geschwind, Jean-Francois ^{[2
]}

机构：

[1] Charite, Dept Diagnost & Intervent Radiol, D-13353 Berlin, Germany

[2] Yale Univ, Sch Med, Dept Diagnost Radiol & Imaging Sci, New Haven, CT 06520 USA

来源：

RADIOLOGY | 2015年 / 276卷 / 02期

关键词：

RADIOFREQUENCY ABLATION; HEPATOCELLULAR-CARCINOMA;

D O I：

10.1148/radiol.2015150451

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

In this issue, Rozenblum et al (1) were able to demonstrate that radiofrequency (RF) ablation-induced liver regeneration promotes "off-target" tumorigenesis in a MDR2 knock-out mouse model of hepatocellular carcinoma (HCC) in the setting of chronic liver inflammation. In addition, the authors demonstrated that blocking liver regeneration with a c-met inhibitor might attenuate or eliminate potential tumorigenic effects. These results provide the rationale for combined therapeutic approaches of RF ablation followed by a systemic application of immunomodulatory drugs.

引用

页码：315 / 317

页数：3

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