Lyotropic behavior of Gelucire 50/13 by XRD, Raman and IR spectroscopies according to hydration

被引：15
作者：
El Hadri, M. [1 ]
Achahbar, A. [1 ]
El Khamkhami, J. [1 ]
Khelifa, B. [2 ,5 ]
Faivre, V. [3 ]
Abbas, O. [4 ]
Bresson, S. [5 ]
机构：
[1] Univ Abdelmalek Essaadi, Lab Phys Mat Condensee, Tetouan, Morocco
[2] Univ Artois, Fac Sci, Lens, France
[3] Univ Paris Sud, Equipe Physicochim Syst Polyphases, UMR CNRS 8612, Labex LERMIT, Paris, France
[4] Walloon Agr Res Ctr CRA W, Valorisat Agr Prod, Food & Feed Qual Unit U15, Henseval Bldg,Chaussee Namur 24, B-5030 Gembloux, Belgium
[5] Univ Picardie Jules Verne, Lab Phys Syst Complexes, 33 Rue St Leu, F-80039 Amiens, France
来源：
CHEMISTRY AND PHYSICS OF LIPIDS | 2016年 / 200卷
关键词：
Gelucire; 50/13; Triglycerides; PEG; Hydration; ATR FTIR; Spectroscopy Raman; SOLID DISPERSIONS; POLYOXYETHYLENE GLYCOL; POLYMORPHIC FORMS; DRUG-DELIVERY; LIQUID-STATE; GLYCERIDES; CRYSTALLIZATION; CALORIMETRY; EXCIPIENT;
D O I：
10.1016/j.chemphyslip.2016.05.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The present paper discuss the structural and vibrational properties of polyoxyethylene glycol glycerides (Gelucire 50/13) during the hydration with increasing water from 0% to 80%. The Gelucire 50/13 used as sustained release matrix forming agent in pharmaceutical applications and it was essentially studied by Small and Wide Angle X-ray Scattering (SWAXS), Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy according to the rate of hydration. The hydration behavior of this amphiphilic excipient has been investigated in the spectral range 4000-0 cm(-1) in Raman spectroscopy, and 4000600 cm(-1) in FTIR. At increasing water contents Gelucire 50/13 forms successive bicontinuous to micellar supramolecular structures, and the vibrational changes were directly correlated with this conformational changes of the Gelucire structure. Overall, Raman and IR spectroscopy clearly demonstrated that the different functional groups studied could be characterized independently, allowing for the understanding of their role in Gelucire polymorphism. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
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页码：11 / 23
页数：13
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