The clinical implications of antitumor immunity in head and neck cancer

被引：45
作者：
Allen, Clint T. [1 ]
Judd, Nancy P. [1 ]
Bui, Jack D. [2 ]
Uppaluri, Ravindra [1 ]
机构：
[1] Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, St Louis, MO 63110 USA
[2] Univ Calif San Diego, Dept Pathol, Sch Med, San Diego, CA 92103 USA
来源：
LARYNGOSCOPE | 2012年 / 122卷 / 01期
关键词：
Tumor immunity; head and neck cancer; standard therapy; immunotherapy; SQUAMOUS-CELL CARCINOMA; ENDOTHELIAL GROWTH-FACTOR; REGULATORY TYPE-1 CELLS; CLASS-I ANTIGEN; DELTA-T-CELLS; COLONY-STIMULATING FACTOR; FACTOR-KAPPA-B; DENDRITIC CELLS; HUMAN-PAPILLOMAVIRUS; TUMOR-ANTIGEN;
D O I：
10.1002/lary.21913
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Recent developments have renewed interest in understanding the interaction between transformed cells and the immune system in the tumor microenvironment. Here, we provide a comprehensive review addressing the basics of tumor immunology in relation to head and neck cancer and the cellular components potentially involved in antitumor immune responses. In addition, we describe the mechanisms by which head and neck cancer cells escape immune-mediated killing and progress to form clinically significant disease. Further, we detail what effects standard anticancer therapies may have on antitumor immune responses and how these responses may be altered by current and investigational immunotherapies. Finally, we discuss future directions that need to be considered in the development of new immunotherapeutics designed to durably alter the immune response in favor of the host.Laryngoscope, 122:144157, 2012
引用
收藏
页码：144 / 157
页数：14
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