Properties of Adult Lung Stem and Progenitor Cells

被引：11

作者：

Bertoncello, Ivan ^{[1
]}

机构：

[1] Univ Melbourne, Lung Hlth Res Ctr, Dept Pharmacol & Therapeut, Melbourne, Vic 3010, Australia

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2016年 / 231卷 / 12期

关键词：

PULMONARY NEUROENDOCRINE CELLS; BRONCHIAL EPITHELIAL-CELLS; TRACHEAL BASAL-CELLS; AIRWAY EPITHELIUM; IN-VITRO; PROXIMAL AIRWAYS; ALVEOLAR CELLS; MOUSE TRACHEA; CLARA CELL; REGENERATION;

D O I：

10.1002/jcp.25404

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The last decade has seen significant progress in understanding the organisation of regenerative cells in the adult lung. Cell-lineage tracing and in vitro clonogenic assays have enabled the identification and characterisation of endogenous lung epithelial stem and progenitor cells. Selective lung injury models, and genetically engineered mice have revealed highly conserved gene networks, factors, signalling pathways, and cellular interactions important in maintaining lung homeostasis and regulating lung regeneration and repair following injury. This review describes the current models of lung epithelial stem and progenitor cell organisation in adult mice, and the impediments encountered in translational studies aiming to identify and characterise their human homologs. (C) 2016 Wiley Periodicals, Inc.

引用

页码：2582 / 2589

页数：8

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