ApoE Type 4 Allele Affects Cognitive Function of Aged Population in Tianjin City, China

被引：5

作者：

Sun, Shoudan ^{[1
,2
]}

Fu, Jingming ^{[1
]}

Chen, Jun ^{[3
]}

Pang, Wei ^{[1
]}

Hu, Ruomei ^{[2
]}

Li, Haiqiang ^{[1
]}

Tan, Long ^{[1
]}

Jiang, Yugang ^{[1
]}

机构：

[1] Tianjin Inst Hlth & Environm Med, Dept Nutr, Tianjin, Peoples R China

[2] Tianjin Hosp, Dept Nutr, Tianjin, Peoples R China

[3] Shandong Univ Tradit Chinese Med, Coll Acupuncture & Tuina, Jinan, Peoples R China

来源：

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS | 2015年 / 30卷 / 05期

关键词：

apolipoprotein E type 4 allele; cognitive function; elderly people; MMSE; basic cognitive aptitude tests; APOLIPOPROTEIN-E EPSILON-4; ALZHEIMERS-DISEASE; OLDER-ADULTS; E GENOTYPE; E GENE; DECLINE; HEALTHY; ONSET; PERFORMANCE; ATTENTION;

D O I：

10.1177/1533317514566114

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Apolipoprotein E type 4 allele (ApoE4) is known as a risk gene for the late-onset Alzheimer's disease, and the relationship between ApoE4 and cognitive function of the elderly people has drawn the attention of the scientists. In this study, we investigated the relationship between ApoE4 and the cognitive function of the old people. A total of 156 old people were investigated, of whom 31 were ApoE4 carriers. The ApoE4 primarily influenced the global cognitive function, perceptual speed, and work memory. The results indicate that ApoE4 has significant negative effect on the cognitive function of the elderly people who are 60 years and older.

引用

页码：503 / 507

页数：5

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