First day of life pulse oximetry screening to detect congenital heart defects

被引：116

作者：

Meberg, Alf ^{[1
]}

Bruegmann-Pieper, Sabine ^{[2
]}

Due, Reidar, Jr. ^{[3
]}

Eskedal, Leif ^{[4
]}

Fagerli, Ingebjorg ^{[5
]}

Farstad, Teresa ^{[6
]}

Froisland, Dag Helge ^{[7
]}

Sannes, Catharina Hovland ^{[8
]}

Johansen, Ole Jakob ^{[9
]}

Keljalic, Jasmina ^{[10
]}

Markestad, Trond ^{[11
]}

Nygaard, Egil Andre ^{[13
]}

Rosvik, Alet ^{[12
]}

Silberg, Inger Elisabeth ^{[14
]}

机构：

[1] Vestfold Hosp, Dept Paediat, N-3103 Tonsberg, Norway

[2] Buskerud Hosp, Dept Paediat, Drammen, Norway

[3] Baerum Hosp, Dept Paediat, Sandvika, Norway

[4] Sorlandet Hosp, Dept Paediat, Kristiansand, Norway

[5] Nordland Hosp, Dept Paediat, Bodo, Norway

[6] Arkershus Univ Hosp, Dept Paediat, Nordbyhagen, Norway

[7] Innlandet Hosp, Dept Paediat, Lillehamer, Norway

[8] Telemark Hosp, Dept Paediat, Skien, Norway

[9] St Olav Hosp, Dept Paediat, Trondheim, Norway

[10] Sorlandet Hosp, Dept Paediat, Arendal, Norway

[11] Innlandet Hosp, Dept Paediat, Gjovik, Norway

[12] Stavanger Univ Hosp, Dept Paediat, Stavanger, Norway

[13] Ostfold Hosp, Dept Paediat, Fredrikstad, Norway

[14] Univ Oslo, Natl Hosp, Dept Paediat, Oslo, Norway

来源：

JOURNAL OF PEDIATRICS | 2008年 / 152卷 / 06期

关键词：

D O I：

10.1016/j.jpeds.2007.12.043

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective To evaluate the efficacy of first day of fife pulse oximetry screening to detect congenital heart defects (CHDs). Study design We performed a population-based prospective multicenter study of postductal (foot) arterial oxygen saturation (SpO(2)) in apparently healthy newborns after transfer from the delivery suite to the nursery. SpO(2) < 95% led to further diagnostic evaluations. Of 57,959 five births, 50,008 (86%) were screened. CHDs were prospectively registered and diagnosed in 658 newborns (1.1%), of whom 35 (5%) were classified as critical (ductus dependent, cyanotic). Results Of the infants screened, 324 (0.6%) failed the test. Of these, 43 (13%) had CHDs (27 critical), and 134 (41%) had pulmonary diseases or other disorders. The remaining 147 infants (45%) were healthy with transitional circulation. The median age for babies with CHDs at failing the test was 6 hours (range, 1-21 hours). For identifying critical CHDs, the pulse oximetry screening had a sensitivity rate of 77.1% (95% CI, 59.4-89.0), specificity rate of 99.4% (95% CI, 99.3-99.5), and a false-positive rate of 0.6% (95% CI, 0.5-0.7). Conclusions Early pulse oximetry screening promotes early detection of critical CHDs and other potentially severe diseases. The sensitivity rate for detecting critical CHDs is high, and the false-positive rate is low.

引用

页码：761 / 765

页数：5

共 26 条

[1] Delayed diagnosis of critical congenital cardiovascular malformations (CCVM) and pulse oximetry screening of newborns [J].