Electrochemiluminescence detection of near single DNA molecules by using quantum dots-dendrimer nanocomposites for signal amplification

被引:49
作者
Divsar, Faten [1 ]
Ju, Huangxian [1 ]
机构
[1] Nanjing Univ, State Key Lab Analyt Chem Life Sci, Dept Chem, Nanjing 210093, Peoples R China
基金
中国国家自然科学基金;
关键词
ELECTROGENERATED CHEMILUMINESCENCE; ELECTRONIC TRANSDUCTION; AQUEOUS-SOLUTION; NUCLEIC-ACIDS; IMMUNOSENSOR; SPECTROSCOPY; LABEL; CELLS; CDTE;
D O I
10.1039/c1cc13592a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
An ultrasensitive electrochemiluminescent biosensor was developed for detection of near single DNA molecules with a linear range of 7 orders of magnitude by combining the specific recognition of a molecular beacon with signal amplification of quantum dots-dendrimer nanocomposites.
引用
收藏
页码:9879 / 9881
页数:3
相关论文
共 29 条
[1]   A novel synergistic enhanced chemiluminescence achieved by a multiplex nanoprobe for biological applications combined with dual-amplification of magnetic nanoparticles [J].
Bi, Sai ;
Zhou, Hong ;
Zhang, Shusheng .
CHEMICAL SCIENCE, 2010, 1 (06) :681-687
[2]   Ultrasensitive and selective DNA detection based on nicking endonuclease assisted signal amplification and its application in cancer cell detection [J].
Bi, Sai ;
Zhang, Jilei ;
Zhang, Shusheng .
CHEMICAL COMMUNICATIONS, 2010, 46 (30) :5509-5511
[3]   Imaging {Au0-PAMAM} gold-dendrimer nanocomposites in cells [J].
Bielinska, A ;
Eichman, JD ;
Lee, I ;
Baker, JR ;
Balogh, L .
JOURNAL OF NANOPARTICLE RESEARCH, 2002, 4 (05) :395-403
[4]   Electrochemistry and electrogenerated chemiluminescence from silicon nanocrystal quantum dots [J].
Ding, ZF ;
Quinn, BM ;
Haram, SK ;
Pell, LE ;
Korgel, BA ;
Bard, AJ .
SCIENCE, 2002, 296 (5571) :1293-1297
[5]   Fluorescence Resonance Energy Transfer between Quantum Dots and Graphene Oxide for Sensing Biomolecules [J].
Dong, Haifeng ;
Gao, Wenchao ;
Yan, Feng ;
Ji, Hanxu ;
Ju, Huangxian .
ANALYTICAL CHEMISTRY, 2010, 82 (13) :5511-5517
[6]   Preparation and characterization of dendrimer-gold colloid nanocomposites [J].
Garcia, ME ;
Baker, LA ;
Crooks, RM .
ANALYTICAL CHEMISTRY, 1999, 71 (01) :256-258
[7]   Synthesis and optical spectroscopy of a hybrid cadmium sulfide-dendrimer nanocomposite [J].
Gayen, S. K. ;
Brito, M. ;
Das, B. B. ;
Comanescu, G. ;
Liang, X. C. ;
Alrubaiee, M. ;
Alfano, R. R. ;
Gonzalez, C. ;
Byro, A. H. ;
Bauer, D. L. V. ;
Balogh-Nair, V. .
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS, 2007, 24 (12) :3064-3071
[8]   Facile synthesis and application of highly luminescent CdTe quantum dots with an electrogenerated precursor [J].
Ge, Cunwang ;
Xu, Min ;
Liu, Jing ;
Lei, Jianping ;
Ju, Huangxian .
CHEMICAL COMMUNICATIONS, 2008, (04) :450-452
[9]   Direct molecular detection of nucleic acids by fluorescence signal amplification [J].
Ho, HA ;
Doré, K ;
Boissinot, M ;
Bergeron, MG ;
Tanguay, RM ;
Boudreau, D ;
Leclerc, M .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (36) :12673-12676
[10]   Pyrene-Excimer Probes Based on the Hybridization Chain Reaction for the Detection of Nucleic Acids in Complex Biological Fluids [J].
Huang, Jin ;
Wu, Yanrong ;
Chen, Yan ;
Zhu, Zhi ;
Yang, Xiaohai ;
Yang, Chaoyong James ;
Wang, Kemin ;
Tan, Weihong .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (02) :401-404