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Can intracellular Staphylococcus aureus in osteomyelitis be treated using current antibiotics? A systematic review and narrative synthesis
被引:47
作者:

Zelmer, Anja R.
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Univ Adelaide, Fac Hlth & Med Sci, Ctr Orthopaed & Trauma Res, Adelaide, SA 5000, Australia Univ Adelaide, Fac Hlth & Med Sci, Ctr Orthopaed & Trauma Res, Adelaide, SA 5000, Australia

Nelson, Renjy
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Cent Adelaide Local Hlth Network, Dept Infect Dis, Adelaide, SA 5000, Australia
Royal Adelaide Hosp, Adelaide, SA 5000, Australia Univ Adelaide, Fac Hlth & Med Sci, Ctr Orthopaed & Trauma Res, Adelaide, SA 5000, Australia

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Atkins, Gerald J.
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Univ Adelaide, Fac Hlth & Med Sci, Ctr Orthopaed & Trauma Res, Adelaide, SA 5000, Australia Univ Adelaide, Fac Hlth & Med Sci, Ctr Orthopaed & Trauma Res, Adelaide, SA 5000, Australia
机构:
[1] Univ Adelaide, Fac Hlth & Med Sci, Ctr Orthopaed & Trauma Res, Adelaide, SA 5000, Australia
[2] Cent Adelaide Local Hlth Network, Dept Infect Dis, Adelaide, SA 5000, Australia
[3] Royal Adelaide Hosp, Adelaide, SA 5000, Australia
[4] Univ Adelaide, Basil Hetzel Inst Translat Hlth Res, Dept Surg, Richter Lab, Adelaide, SA 5011, Australia
关键词:
SMALL-COLONY VARIANTS;
PROSTHETIC JOINT INFECTIONS;
FUSIDIC ACID;
PHARMACODYNAMIC EVALUATION;
IN-VITRO;
STREPTOCOCCUS-PNEUMONIAE;
LISTERIA-MONOCYTOGENES;
DELIVERY-SYSTEM;
DRUG-DELIVERY;
CLINICAL-USE;
D O I:
10.1038/s41413-022-00227-8
中图分类号:
Q813 [细胞工程];
学科分类号:
摘要:
Approximately 40% of treatments of chronic and recurrent osteomyelitis fail in part due to bacterial persistence. Staphylococcus aureus, the predominant pathogen in human osteomyelitis, is known to persist by phenotypic adaptation as small-colony variants (SCVs) and by formation of intracellular reservoirs, including those in major bone cell types, reducing susceptibility to antibiotics. Intracellular infections with S. aureus are difficult to treat; however, there are no evidence-based clinical guidelines addressing these infections in osteomyelitis. We conducted a systematic review of the literature to determine the demonstrated efficacy of all antibiotics against intracellular S. aureus relevant to osteomyelitis, including protein biosynthesis inhibitors (lincosamides, streptogramins, macrolides, oxazolidines, tetracyclines, fusidic acid, and aminoglycosides), enzyme inhibitors (fluoroquinolones and ansamycines), and cell wall inhibitors (beta-lactam inhibitors, glycopeptides, fosfomycin, and lipopeptides). The PubMed and Embase databases were screened for articles related to intracellular S. aureus infections that compared the effectiveness of multiple antibiotics or a single antibiotic together with another treatment, which resulted in 34 full-text articles fitting the inclusion criteria. The combined findings of these studies were largely inconclusive, most likely due to the plethora of methodologies utilized. Therefore, the reported findings in the context of the models employed and possible solutions for improved understanding are explored here. While rifampicin, oritavancin, linezolid, moxifloxacin and oxacillin were identified as the most effective potential intracellular treatments, the scientific evidence for these is still relatively weak. We advocate for more standardized research on determining the intracellular effectiveness of antibiotics in S. aureus osteomyelitis to improve treatments and patient outcomes.
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- [1] Lysosomal alkalization to potentiate eradication of intra-osteoblastic Staphylococcus aureus in the bone and joint infection setting[J]. CLINICAL MICROBIOLOGY AND INFECTION, 2022, 28 (01) : 135.e1 - 135.e7Abad, Lelia论文数: 0 引用数: 0 h-index: 0机构: Univ Lyon, CIRI Ctr Int Rech Infectiol, Univ Claude Bernard Lyon 1, Ecole Normale Super Lyon,Inserm U1111,CNRS,UMR530, F-69007 Lyon, France Univ Claude Bernard Lyon 1, Lyon, France Hosp Civils Lyon, Lab Bacteriol, Inst Agents Infectieux, French Natl Reference Ctr Staphylococci, Lyon, France Univ Lyon, CIRI Ctr Int Rech Infectiol, Univ Claude Bernard Lyon 1, Ecole Normale Super Lyon,Inserm U1111,CNRS,UMR530, F-69007 Lyon, FranceChauvelot, Pierre论文数: 0 引用数: 0 h-index: 0机构: Hosp Civils Lyon, Ctr Reference Prise Charge Infect Osteoarticulair, Lyon, France Hosp Civils Lyon, Serv Malad Infect & Trop, Lyon, France Univ Lyon, CIRI Ctr Int Rech Infectiol, Univ Claude Bernard Lyon 1, Ecole Normale Super Lyon,Inserm U1111,CNRS,UMR530, F-69007 Lyon, FranceAudoux, Estelle论文数: 0 引用数: 0 h-index: 0机构: Univ Jean Monnet, Ctr Int Rech Infectiol, Equipe GIMAP, CIRI,Univ Lyon,INSERM U1111,CNRS,ENS,UCBL1, St Etienne, France Univ Lyon, CIRI Ctr Int Rech Infectiol, Univ Claude Bernard Lyon 1, Ecole Normale Super Lyon,Inserm U1111,CNRS,UMR530, F-69007 Lyon, FranceAndre, Camille论文数: 0 引用数: 0 h-index: 0机构: Univ Claude Bernard Lyon 1, Lyon, France Hosp Civils Lyon, Lab Bacteriol, Inst Agents Infectieux, French Natl Reference Ctr Staphylococci, Lyon, France Univ Lyon, CIRI Ctr Int Rech Infectiol, Univ Claude Bernard Lyon 1, Ecole Normale Super Lyon,Inserm U1111,CNRS,UMR530, F-69007 Lyon, FranceJosse, Jerome论文数: 0 引用数: 0 h-index: 0机构: Univ Lyon, CIRI Ctr Int Rech Infectiol, Univ Claude Bernard Lyon 1, Ecole Normale Super Lyon,Inserm U1111,CNRS,UMR530, F-69007 Lyon, France Univ Claude Bernard Lyon 1, Lyon, France Univ Lyon, CIRI Ctr Int Rech Infectiol, Univ Claude Bernard Lyon 1, Ecole Normale Super Lyon,Inserm U1111,CNRS,UMR530, F-69007 Lyon, FranceDupieux, Celine论文数: 0 引用数: 0 h-index: 0机构: Univ Lyon, CIRI Ctr Int Rech Infectiol, Univ Claude Bernard Lyon 1, Ecole Normale Super Lyon,Inserm U1111,CNRS,UMR530, F-69007 Lyon, France Univ Claude Bernard Lyon 1, Lyon, France Hosp Civils Lyon, Lab Bacteriol, Inst Agents Infectieux, French Natl Reference Ctr Staphylococci, Lyon, France Hosp Civils Lyon, Ctr Reference Prise Charge Infect Osteoarticulair, Lyon, France Univ Lyon, CIRI Ctr Int Rech Infectiol, Univ Claude Bernard Lyon 1, Ecole Normale Super Lyon,Inserm U1111,CNRS,UMR530, F-69007 Lyon, France论文数: 引用数: h-index:机构:论文数: 引用数: h-index:机构:Verhoeven, Paul O.论文数: 0 引用数: 0 h-index: 0机构: Univ Jean Monnet, Ctr Int Rech Infectiol, Equipe GIMAP, CIRI,Univ Lyon,INSERM U1111,CNRS,ENS,UCBL1, St Etienne, France CHU St Etienne, Serv Agents Infectieux & Hyg, St Etienne, France Univ Lyon, CIRI Ctr Int Rech Infectiol, Univ Claude Bernard Lyon 1, Ecole Normale Super Lyon,Inserm U1111,CNRS,UMR530, F-69007 Lyon, FranceDiot, Alan论文数: 0 引用数: 0 h-index: 0机构: Univ Lyon, CIRI Ctr Int Rech Infectiol, Univ Claude Bernard Lyon 1, Ecole Normale Super Lyon,Inserm U1111,CNRS,UMR530, F-69007 Lyon, France Univ Lyon, CIRI Ctr Int Rech Infectiol, Univ Claude Bernard Lyon 1, Ecole Normale Super Lyon,Inserm U1111,CNRS,UMR530, F-69007 Lyon, France论文数: 引用数: h-index:机构:论文数: 引用数: h-index:机构:
- [2] Antibiofilm and intraosteoblastic activities of rifamycins against Staphylococcus aureus: promising in vitro profile of rifabutin[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2020, 75 (06) : 1466 - 1473Abad, Lelia论文数: 0 引用数: 0 h-index: 0机构: Univ Claude Bernard Lyon 1, Univ Lyon, CIRI Ctr Int Rech Infectiol, Ecole Normale Super Lyon,Inserm,U1111,CNRS,UMR530, F-69007 Lyon, France Univ Claude Bernard Lyon 1, Lyon, France Hosp Civils Lyon, French Natl Reference Ctr Staphylococci, Inst Agents Infect, Lab Bacteriol, Lyon, France Univ Claude Bernard Lyon 1, Univ Lyon, CIRI Ctr Int Rech Infectiol, Ecole Normale Super Lyon,Inserm,U1111,CNRS,UMR530, F-69007 Lyon, FranceJosse, Jerome论文数: 0 引用数: 0 h-index: 0机构: Univ Claude Bernard Lyon 1, Univ Lyon, CIRI Ctr Int Rech Infectiol, Ecole Normale Super Lyon,Inserm,U1111,CNRS,UMR530, F-69007 Lyon, France Univ Claude Bernard Lyon 1, Univ Lyon, CIRI Ctr Int Rech Infectiol, Ecole Normale Super Lyon,Inserm,U1111,CNRS,UMR530, F-69007 Lyon, France论文数: 引用数: h-index:机构:论文数: 引用数: h-index:机构:论文数: 引用数: h-index:机构:Diot, Alan论文数: 0 引用数: 0 h-index: 0机构: Univ Claude Bernard Lyon 1, Univ Lyon, CIRI Ctr Int Rech Infectiol, Ecole Normale Super Lyon,Inserm,U1111,CNRS,UMR530, F-69007 Lyon, France Univ Claude Bernard Lyon 1, Univ Lyon, CIRI Ctr Int Rech Infectiol, Ecole Normale Super Lyon,Inserm,U1111,CNRS,UMR530, F-69007 Lyon, France论文数: 引用数: h-index:机构:论文数: 引用数: h-index:机构:
- [3] Evaluation of the ability of linezolid and tedizolid to eradicate intraosteoblastic and biofilm-embedded Staphylococcus aureus in the bone and joint infection setting[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2019, 74 (03) : 625 - 632Abad, Lelia论文数: 0 引用数: 0 h-index: 0机构: Univ Lyon, Ecole Normale Superieure Lyon, CIRI Inserm U1111,UMR5308, Univ Claude Bernard Lyon 1, F-69007 Lyon, France Hospices Civils Lyon, Reg Reference Ctr Complex Bone & Joint Infect, CRIOAc Lyon, Hospices Civils Lyon, Lyon, France Univ Claude Bernard Lyon 1, Lyon, France Hospices Civils Lyon, Inst Infect Agents, Dept Bacteriol, Lyon, France Univ Lyon, Ecole Normale Superieure Lyon, CIRI Inserm U1111,UMR5308, Univ Claude Bernard Lyon 1, F-69007 Lyon, FranceTafani, Virginie论文数: 0 引用数: 0 h-index: 0机构: Univ Lyon, Ecole Normale Superieure Lyon, CIRI Inserm U1111,UMR5308, Univ Claude Bernard Lyon 1, F-69007 Lyon, France Univ Lyon, Ecole Normale Superieure Lyon, CIRI Inserm U1111,UMR5308, Univ Claude Bernard Lyon 1, F-69007 Lyon, France论文数: 引用数: h-index:机构:Josse, Jerome论文数: 0 引用数: 0 h-index: 0机构: Univ Lyon, Ecole Normale Superieure Lyon, CIRI Inserm U1111,UMR5308, Univ Claude Bernard Lyon 1, F-69007 Lyon, France Univ Lyon, Ecole Normale Superieure Lyon, CIRI Inserm U1111,UMR5308, Univ Claude Bernard Lyon 1, F-69007 Lyon, France论文数: 引用数: h-index:机构:论文数: 引用数: h-index:机构:论文数: 引用数: h-index:机构:Diot, Alan论文数: 0 引用数: 0 h-index: 0机构: Univ Lyon, Ecole Normale Superieure Lyon, CIRI Inserm U1111,UMR5308, Univ Claude Bernard Lyon 1, F-69007 Lyon, France Univ Lyon, Ecole Normale Superieure Lyon, CIRI Inserm U1111,UMR5308, Univ Claude Bernard Lyon 1, F-69007 Lyon, France论文数: 引用数: h-index:机构:论文数: 引用数: h-index:机构:
- [4] Nanocarriers for antibiotics: A promising solution to treat intracellular bacterial infections[J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2014, 43 (06) : 485 - 496Abed, Nadia论文数: 0 引用数: 0 h-index: 0机构: Univ Paris 11, Fac Pharm, Inst Galien, UMR CNRS 8612, F-92296 Chatenay Malabry, France Univ Paris 11, Fac Pharm, Inst Galien, UMR CNRS 8612, F-92296 Chatenay Malabry, FranceCouvreur, Patrick论文数: 0 引用数: 0 h-index: 0机构: Univ Paris 11, Fac Pharm, Inst Galien, UMR CNRS 8612, F-92296 Chatenay Malabry, France Univ Paris 11, Fac Pharm, Inst Galien, UMR CNRS 8612, F-92296 Chatenay Malabry, France
- [5] Treatment of staphylococcal prosthetic joint infections with debridement, prosthesis retention and oral rifampicin and fusidic acid[J]. CLINICAL MICROBIOLOGY AND INFECTION, 2007, 13 (06) : 586 - 591Aboltins, C. A.论文数: 0 引用数: 0 h-index: 0机构: St Vincents Hosp, Dept Infect Dis, Fitzroy, Vic 3065, AustraliaPage, M. A.论文数: 0 引用数: 0 h-index: 0机构: St Vincents Hosp, Dept Infect Dis, Fitzroy, Vic 3065, AustraliaBuising, K. L.论文数: 0 引用数: 0 h-index: 0机构: St Vincents Hosp, Dept Infect Dis, Fitzroy, Vic 3065, AustraliaJenney, A. W. J.论文数: 0 引用数: 0 h-index: 0机构: St Vincents Hosp, Dept Infect Dis, Fitzroy, Vic 3065, AustraliaDaffy, J. R.论文数: 0 引用数: 0 h-index: 0机构: St Vincents Hosp, Dept Infect Dis, Fitzroy, Vic 3065, AustraliaChoong, P. F. M.论文数: 0 引用数: 0 h-index: 0机构: St Vincents Hosp, Dept Infect Dis, Fitzroy, Vic 3065, AustraliaStanley, P. A.论文数: 0 引用数: 0 h-index: 0机构: St Vincents Hosp, Dept Infect Dis, Fitzroy, Vic 3065, Australia
- [6] Conservative management of diabetic foot osteomyelitis[J]. DIABETES RESEARCH AND CLINICAL PRACTICE, 2013, 101 (03) : E18 - E20Acharya, S.论文数: 0 引用数: 0 h-index: 0机构: Lancashire Teaching Hosp, Dept Med, Chorley PR7 1PP, Lancs, England Lancashire Teaching Hosp, Dept Med, Chorley PR7 1PP, Lancs, EnglandSoliman, M.论文数: 0 引用数: 0 h-index: 0机构: Lancashire Teaching Hosp, Dept Med, Chorley PR7 1PP, Lancs, England Lancashire Teaching Hosp, Dept Med, Chorley PR7 1PP, Lancs, EnglandEgun, A.论文数: 0 引用数: 0 h-index: 0机构: Lancashire Teaching Hosp, Dept Vasc Surg, Chorley PR7 1PP, Lancs, England Lancashire Teaching Hosp, Dept Med, Chorley PR7 1PP, Lancs, EnglandRajbhandari, S. M.论文数: 0 引用数: 0 h-index: 0机构: Lancashire Teaching Hosp, Dept Med, Chorley PR7 1PP, Lancs, England Univ Cent Lancashire, Preston PR1 2HE, Lancs, England Lancashire Teaching Hosp, Dept Med, Chorley PR7 1PP, Lancs, England
- [7] A literature review of perioperative antibiotic administration in surgery for medication-related osteonecrosis of the jaw[J]. Oral and Maxillofacial Surgery, 2018, 22 (4) : 369 - 378Akashi M.论文数: 0 引用数: 0 h-index: 0机构: Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, KobeKusumoto J.论文数: 0 引用数: 0 h-index: 0机构: Department of Oral and Maxillofacial Surgery, Kakogawa Central City Hospital, 439 Honmachi, Kakogawa-cho, Kakogawa Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, KobeTakeda D.论文数: 0 引用数: 0 h-index: 0机构: Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, KobeShigeta T.论文数: 0 引用数: 0 h-index: 0机构: Department of Oral and Maxillofacial Surgery, Hyogo Cancer Center, 13-70 Kitaouji-cho, Akashi Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, KobeHasegawa T.论文数: 0 引用数: 0 h-index: 0机构: Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, KobeKomori T.论文数: 0 引用数: 0 h-index: 0机构: Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe
- [8] Macrolides from rare actinomycetes: Structures and bioactivities[J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2022, 59 (02)Al-Fadhli, Ammar A.论文数: 0 引用数: 0 h-index: 0机构: Sanaa Univ, Fac Sci, Dept Chem, Sanaa, Yemen Aberystwyth Univ, Inst Biol Environm & Rural Sci IBERS, Aberystwyth SY23 3DA, Dyfed, Wales Sanaa Univ, Fac Sci, Dept Chem, Sanaa, YemenThreadgill, MichaelD.论文数: 0 引用数: 0 h-index: 0机构: Aberystwyth Univ, Inst Biol Environm & Rural Sci IBERS, Aberystwyth SY23 3DA, Dyfed, Wales Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England Sanaa Univ, Fac Sci, Dept Chem, Sanaa, Yemen论文数: 引用数: h-index:机构:Sibley, Paul论文数: 0 引用数: 0 h-index: 0机构: Univ Guelph, Sch Environm Sci, 50 Stone Rd E, Guelph, ON N1G 2W1, Canada Sanaa Univ, Fac Sci, Dept Chem, Sanaa, YemenAl-Ariqi, Wadie论文数: 0 引用数: 0 h-index: 0机构: Sanaa Univ, Fac Sci, Dept Chem, Sanaa, Yemen Sanaa Univ, Fac Sci, Dept Chem, Sanaa, YemenParveen, Ifat论文数: 0 引用数: 0 h-index: 0机构: Aberystwyth Univ, Inst Biol Environm & Rural Sci IBERS, Aberystwyth SY23 3DA, Dyfed, Wales Sanaa Univ, Fac Sci, Dept Chem, Sanaa, Yemen
- [9] Intracellular Staphylococcus aureus in bone and joint infections: A mechanism of disease recurrence, inflammation, and bone and cartilage destruction[J]. BONE, 2020, 141Alder, Kareme D.论文数: 0 引用数: 0 h-index: 0机构: Yale Univ, Sch Med, Dept Orthopaed & Rehabil, 330 Cedar St,TMP 523,POB 208071, New Haven, CT 06520 USA Yale Univ, Sch Med, Dept Orthopaed & Rehabil, 330 Cedar St,TMP 523,POB 208071, New Haven, CT 06520 USALee, Inkyu论文数: 0 引用数: 0 h-index: 0机构: Yale Univ, Sch Med, Dept Orthopaed & Rehabil, 330 Cedar St,TMP 523,POB 208071, New Haven, CT 06520 USA Chung Ang Univ, Dept Life Sci, Seoul, South Korea Yale Univ, Sch Med, Dept Orthopaed & Rehabil, 330 Cedar St,TMP 523,POB 208071, New Haven, CT 06520 USAMunger, Alana M.论文数: 0 引用数: 0 h-index: 0机构: Yale Univ, Sch Med, Dept Orthopaed & Rehabil, 330 Cedar St,TMP 523,POB 208071, New Haven, CT 06520 USA Yale Univ, Sch Med, Dept Orthopaed & Rehabil, 330 Cedar St,TMP 523,POB 208071, New Haven, CT 06520 USAKwon, Hyuk-Kwon论文数: 0 引用数: 0 h-index: 0机构: Yale Univ, Sch Med, Dept Orthopaed & Rehabil, 330 Cedar St,TMP 523,POB 208071, New Haven, CT 06520 USA Yale Univ, Sch Med, Dept Orthopaed & Rehabil, 330 Cedar St,TMP 523,POB 208071, New Haven, CT 06520 USAMorris, Montana T.论文数: 0 引用数: 0 h-index: 0机构: Yale Univ, Sch Med, Dept Orthopaed & Rehabil, 330 Cedar St,TMP 523,POB 208071, New Haven, CT 06520 USA Yale Univ, Sch Med, Dept Orthopaed & Rehabil, 330 Cedar St,TMP 523,POB 208071, New Haven, CT 06520 USACahill, Sean V.论文数: 0 引用数: 0 h-index: 0机构: Yale Univ, Sch Med, Dept Orthopaed & Rehabil, 330 Cedar St,TMP 523,POB 208071, New Haven, CT 06520 USA Yale Univ, Sch Med, Dept Orthopaed & Rehabil, 330 Cedar St,TMP 523,POB 208071, New Haven, CT 06520 USABack, JungHo论文数: 0 引用数: 0 h-index: 0机构: Yale Univ, Sch Med, Dept Orthopaed & Rehabil, 330 Cedar St,TMP 523,POB 208071, New Haven, CT 06520 USA Yale Univ, Sch Med, Dept Orthopaed & Rehabil, 330 Cedar St,TMP 523,POB 208071, New Haven, CT 06520 USAYu, Kristin E.论文数: 0 引用数: 0 h-index: 0机构: Yale Univ, Sch Med, Dept Orthopaed & Rehabil, 330 Cedar St,TMP 523,POB 208071, New Haven, CT 06520 USA Yale Univ, Sch Med, Dept Orthopaed & Rehabil, 330 Cedar St,TMP 523,POB 208071, New Haven, CT 06520 USALee, Francis Y.论文数: 0 引用数: 0 h-index: 0机构: Yale Univ, Sch Med, Dept Orthopaed & Rehabil, 330 Cedar St,TMP 523,POB 208071, New Haven, CT 06520 USA Yale Univ, Sch Med, Dept Orthopaed & Rehabil, 330 Cedar St,TMP 523,POB 208071, New Haven, CT 06520 USA
- [10] Factors influencing the internalization of Staphylococcus aureus and impacts on the course of infections in humans[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2001, 56 (3-4) : 361 - 366Alexander, EH论文数: 0 引用数: 0 h-index: 0机构: Univ N Carolina, Dept Biol, Charlotte, NC 28223 USA Univ N Carolina, Dept Biol, Charlotte, NC 28223 USAHudson, MC论文数: 0 引用数: 0 h-index: 0机构: Univ N Carolina, Dept Biol, Charlotte, NC 28223 USA Univ N Carolina, Dept Biol, Charlotte, NC 28223 USA