The relationship between cognitive deficits and everyday functional activities in multiple sclerosis

被引:126
作者
Kalmar, Jessica H. [3 ]
Halper, June [2 ]
Gaudino, Elizabeth A. [1 ]
Moore, Nancy B. [1 ]
DeLuca, John
机构
[1] Kessler Med Rehabil Res & Educ Ctr, Neuropsychol & Neurosci Lab, W Orange, NJ 07052 USA
[2] Holy Name Hosp, Teaneck, NJ USA
[3] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA
关键词
multiple sclerosis; cognition; activities of daily living; executive functions;
D O I
10.1037/0894-4105.22.4.442
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Considerable evidence indicates that cognitive dysfunction and impairments in everyday life activities are common in multiple sclerosis (MS). However, the relationship between these cognitive and functional deficits has not been thoroughly investigated. The purpose of this study was to examine the role of cognitive dysfunction in the functional status of individuals with MS. Participants were 74 adults with MS and 35 healthy comparison participants (HCs) who underwent neuropsychological testing and completed the Executive Functions Performance Test (EFPT; Baum, Morrison, Hahn, & Edwards, 2003), an objective measure of everyday life activities. Between-groups comparisons and correlational analyses were conducted to examine the relationship between cognition and functional capacity. Significant differences in EFPT performance were revealed between individuals with MS with and without cognitive impairment and HCs. In individuals with MS, performance on cognitive constructs was related to performance on the EFPT. Furthermore, a linear regression model comprised of indices of cognitive functioning explained a significant portion of the variance in everyday life activities. Findings suggest that individuals with and without cognitive impairment differ in functional status and that aspects of cognition are predictive of functional status in MS.
引用
收藏
页码:442 / 449
页数:8
相关论文
共 56 条
[1]   COGNITIVE IMPAIRMENT IN EARLY-ONSET MULTIPLE-SCLEROSIS - PATTERN, PREDICTORS, AND IMPACT ON EVERYDAY LIFE IN A 4-YEAR FOLLOW-UP [J].
AMATO, MP ;
PONZIANI, G ;
PRACUCCI, G ;
BRACCO, L ;
SIRACUSA, G ;
AMADUCCI, L .
ARCHIVES OF NEUROLOGY, 1995, 52 (02) :168-172
[2]   Cognitive dysfunction in early-onset multiple sclerosis - A reappraisal after 10 years [J].
Amato, MP ;
Ponziani, G ;
Siracusa, G ;
Sorbi, S .
ARCHIVES OF NEUROLOGY, 2001, 58 (10) :1602-1606
[3]  
Archibald CJ, 2000, J CLIN EXP NEUROPSYC, V22, P686, DOI 10.1076/1380-3395(200010)22:5
[4]  
1-9
[5]  
FT686
[6]   Executive functions in multiple sclerosis: An analysis of temporal ordering, semantic encoding, and planning abilities [J].
Arnett, PA ;
Rao, SM ;
Grafman, J ;
Bernardin, L ;
Luchetta, T ;
Binder, JR ;
Lobeck, L .
NEUROPSYCHOLOGY, 1997, 11 (04) :535-544
[7]  
BARBIZET J, 1968, INT J NEUROL, V7, P44
[8]   COGNITIVE PERFORMANCE IN SENILE DEMENTIA OF THE ALZHEIMER TYPE - THE KITCHEN TASK ASSESSMENT [J].
BAUM, C ;
EDWARDS, DF .
AMERICAN JOURNAL OF OCCUPATIONAL THERAPY, 1993, 47 (05) :431-436
[9]  
BAUM CM, AM J OCCUPA IN PRESS
[10]  
Baum CM T., 2003, Test manual: executive function performance test