Oleanane triterpenes with protein tyrosine phosphatase 1B inhibitory activity from aerial parts of Lantana camara collected in Indonesia and Japan

被引：19

作者：

Abdjul, Delfly B. ^{[1
,2
]}

Yamazaki, Hiroyuki ^{[1
]}

Maarisit, Wilmar ^{[1
,3
]}

Rotinsulu, Henki ^{[4
]}

Wewengkang, Defny S. ^{[4
]}

Sumilat, Deiske A. ^{[3
]}

Kapojos, Magie M. ^{[5
]}

Losung, Fitje ^{[3
]}

Ukai, Kazuyo ^{[1
]}

Namikoshi, Michio ^{[1
]}

机构：

[1] Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Sendai, Miyagi 9818558, Japan

[2] North Sulawesi Res & Dev Agcy, 17 Agustus St, Manado 95117, Indonesia

[3] Sam Ratulangi Univ, Fac Fisheries & Marine Sci, Kampus Bahu, Manado 95115, Indonesia

[4] Sam Ratulangi Univ, Fac Math & Nat Sci, Kampus Bahu, Manado 95115, Indonesia

[5] Univ Pembangunan Indonesia, Fac Nursing, Bahu 95115, Manado, Indonesia

来源：

PHYTOCHEMISTRY | 2017年 / 144卷

关键词：

Lantana camara L; Verbenaceae; Oleanane triterpene; Phytochemical profile; Protein tyrosine phosphatase 1B; Inhibitor; 22-BETA-ANGELOYLOXY-3-OXOOLEAN-12-EN-28-OIC ACID; GLYCOGEN-PHOSPHORYLASE; OLEANOLIC ACID; LANTADENE-A; RED VARIETY; DERIVATIVES; TARGET; ETHER; PTP1B; ROOT;

D O I：

10.1016/j.phytochem.2017.08.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During the search for new protein tyrosine phosphatase (PTP) 1B inhibitors, EtOH extracts from the aerial parts of Lantana camara L (lantana) collected at Manado (Indonesia) and two subtropical islands in Japan (Ishigaki and Iriomote Islands, Okinawa) exhibited potent inhibitory activities against PTP1B in an enzyme assay. Four previously undescribed oleanane triterpenes were isolated together with known triterpenes and fiavones from the Indonesian lantana. The EtOH extracts of lantana collected in Ishigaki and Iriomote Islands exhibited different phytochemical profiles from each other and the Indonesian lantana. Triterpenes with a 24-OH group were isolated from the Indonesian lantana only. Five known triterpene compounds were detected in the Ishigaki lantana, and two oleanane triterpenes with an ether linkage between 3 beta and 25 were the main components together with five known triterpenes as minor components in the Iriomote lantana. The structures of previously undescribed compounds were assigned on the basis of their spectroscopic data. Among the compounds obtained in this study, oleanolic acid exhibited the most potent activity against PTP1B, and is used as a positive control in studies on PTP1B. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：106 / 112

页数：7

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