Chemical activation of MEK1-a redox trigger for evaluating the effects of phosphorylation

被引：5

作者：

Lamoureaux, Toni L. ^{[1
]}

Lee, David H. ^{[1
]}

机构：

[1] Tufts Univ, Dept Chem, Medford, MA 02155 USA

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 30期

关键词：

TANDEM MASS-SPECTROMETRY; TGF-BETA RECEPTOR; POSTTRANSLATIONAL MODIFICATIONS; KINASE ACTIVATION; PROTEIN; IDENTIFICATION; SITE; CHEMISTRY; MECHANISM; PEPTIDES;

D O I：

10.1039/c1cc11745a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An approach to generate mimics of phosphorylated serine proteins chemically through site-specific sulfonation of cysteine is presented. This chemical modification is reversible in the presence of reducing agent and therefore is analogous to the kinase/phosphatase system used in nature.

引用

页码：8623 / 8625

页数：3

共 2 条

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