Toll-like receptor 9 ligands increase type I interferon induced B-cell activating factor expression in chronic rhinosinusitis with nasal polyposis

被引：8
作者：
Xu, Jun [1 ,4 ,5 ]
Lee, Jin-Woo [1 ]
Park, Soo-Kyoung [1 ]
Lee, Sung-Bok [2 ]
Yoon, Young-Hoon [1 ]
Yeon, Sun-Hee [1 ]
Rha, Ki-Sang [1 ]
Choi, Ji-Ae [3 ]
Song, Chang-Hwa [3 ]
Kim, Yong Min [1 ]
机构：
[1] Chungnam Natl Univ, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Res Inst Med Sci, Daejeon, South Korea
[2] Chungnam Natl Univ, Sch Med, Chungnam Natl Univ Hosp, Dept Ophthalmol, Daejeon, South Korea
[3] Chungnam Natl Univ, Coll Med, Dept Microbiol, Daejeon, South Korea
[4] Guangzhou Med Univ, Affiliated Hosp 1, Dept Otorhinolaryngol Head & Neck Surg, State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China
[5] Yanbian Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Yanji, Jilin, Peoples R China
来源：
CLINICAL IMMUNOLOGY | 2018年 / 197卷
基金：
新加坡国家研究基金会;
关键词：
B-cell activating factor; Sinusitis; Nasal polyp; Toll-like receptor; Type I interferon; PLASMACYTOID DENDRITIC CELLS; ALPHA-PRODUCING CELLS; IMMUNE-COMPLEXES; BACTERIAL-DNA; SELF-DNA; C-CLASS; CPG; AUTOIMMUNITY; INFECTION; RESPONSES;
D O I：
10.1016/j.clim.2018.07.014
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
B-cell activating factor (BAFF) has been proposed to play a crucial role in the pathogenesis of chronic rhinosinusitis with nasal polyp (CRSwNP). The aim of this study was to evaluate the role of toll-like receptor (TLR) 9 mediated BAFF activation on the pathogenesis of CRSwNP. NP and uncinate tissue (UT) were obtained from patients with CRSwNP or CRS without NP, and control subjects. The expression of TLR9, high mobility group box-1 protein (HMGB1), type I interferon (IFN), BAFF, and anti-double stranded DNA (dsDNA) antibody were examined in the tissues and the cultured dispersed NP cells (DNPCs). The expression of TLR9, HMGB1, type I IFN, BAFF, and anti-dsDNA antibody were elevated in NP tissue compared to the UTs. Exposure to TLR9 agonist increased the type I IFN expression in vitro, which further increased BAFF production. In conclusion, we provided a novel therapeutic potential of TLR9 agonist in CRSwNP.
引用
收藏
页码：19 / 26
页数：8
相关论文
共 45 条
  • [1] Deoxycytidyl-deoxyguanosine oligonucleotide classes A, B, and C induce distinct ctokine gene expression patterns in rhesus monkey peripheral blood mononuclear cells and distinct alpha interferon responses in TLR9-expressing rhesus monkey plasmacytoid dendritic cells
    Abel, K
    Wang, YC
    Fritts, L
    Sanchez, E
    Chung, E
    Fitzgerald-Bocarsly, P
    Krieg, AM
    Miller, CJ
    [J]. CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2005, 12 (05) : 606 - 621
  • [2] Ashkar Ali A., 2002, Current Molecular Medicine (Hilversum), V2, P545, DOI 10.2174/1566524023362159
  • [3] Production of type I interferons: plasmacytoid dendritic cells and beyond
    Asselin-Paturel, C
    Trinchieri, G
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (04) : 461 - 465
  • [4] Type I interferon in systemic lupus erythematosus and other autoimmune diseases
    Banchereau, Jacques
    Pascual, Virginia
    [J]. IMMUNITY, 2006, 25 (03) : 383 - 392
  • [5] Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
    Barton, GM
    Kagan, JC
    Medzhitov, R
    [J]. NATURE IMMUNOLOGY, 2006, 7 (01) : 49 - 56
  • [6] Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
    Bauer, S
    Kirschning, CJ
    Häcker, H
    Redecke, V
    Hausmann, S
    Akira, S
    Wagner, H
    Lipford, GB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (16) : 9237 - 9242
  • [7] Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes
    Boulé, MW
    Broughton, C
    Mackay, F
    Akira, S
    Marshak-Rothstein, A
    Rifkin, IR
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (12) : 1631 - 1640
  • [8] Fokkens WJ, 2012, RHINOLOGY, V50, P1, DOI 10.4193/Rhin20.600
  • [9] Differences between interferon-α and -β treatment for patients with chronic hepatitis C virus infection
    Furusyo, N
    Hayashi, J
    Ohmiya, M
    Sawayama, Y
    Kawakami, Y
    Ariyama, I
    Kinukawa, N
    Kashiwagi, S
    [J]. DIGESTIVE DISEASES AND SCIENCES, 1999, 44 (03) : 608 - 617
  • [10] Extracellular eosinophilic traps in association with Staphylococcus aureus at the site of epithelial barrier defects in patients with severe airway inflammation
    Gevaert, Elien
    Zhang, Nan
    Krysko, Olga
    Lan, Feng
    Holtappels, Gabriele
    De Ruyck, Natalie
    Nauwynck, Hans
    Yousefi, Shida
    Simon, Hans-Uwe
    Bachert, Claus
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 139 (06) : 1849 - +
12345