Association of SNPs in genes encoding zinc transporters on blood zinc levels in humans

被引：9

作者：

Fujihara, Junko ^{[1
]}

Yasuda, Toshihiro ^{[2
]}

Kimura-Kataoka, Kaori ^{[1
]}

Takinami, Yoshikazu ^{[3
]}

Nagao, Masataka ^{[4
]}

Takeshita, Haruo ^{[1
]}

机构：

[1] Shimane Univ, Sch Med, Dept Legal Med, Izumo, Shimane 6938501, Japan

[2] Univ Fukui, Fac Med Sci, Dept Med Genet & Biochem, Fukui 9101193, Japan

[3] Shimane Univ, Fac Med, Dept Emergency & Crit Care Med, Izumo, Shimane 6938501, Japan

[4] Hiroshima Univ, Grad Sch Biomed Sci, Dept Legal Med, Hiroshima 7348553, Japan

来源：

LEGAL MEDICINE | 2018年 / 30卷

关键词：

Zinc; Single nucleotide polymorphism; Zinc transporters; Blood levels; SERUM CONCENTRATIONS; JAPANESE POPULATION; ADULT HEIGHT; WHOLE-BLOOD; POLYMORPHISMS; NANOPARTICLES; SLC30A3; METALS; FAMILY; URINE;

D O I：

10.1016/j.legalmed.2017.10.009

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Zinc homeostasis in cells depends on zinc transporters, which are divided into 2 families: ZnT (SLC30A) and ZIP (SLC39A). In this study, we examined the effect of 20 single nucleotide polymorphisms (SNPs) in 10 genes encoding zinc transporters on blood zinc concentration in Japanese subjects (n = 102). Blood zinc levels were determined by microwave plasma-atomic emission spectrometry, and SNPs were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism analysis. Among the 20 SNPs examined, 3 SNPs (SLC30A3 rs11126936, SLC39A8 rs233804, and SLC39A14 rs4872479) were significantly associated with blood zinc concentration. Individuals with genotype TT and TG in rs11126936 showed significantly higher blood zinc concentrations than those with GG. As for rs233804, individuals harboring the A allele had significantly higher blood zinc concentrations than those without this allele. Furthermore, the genotype TT and TG in rs4872479 had significantly higher blood zinc concentrations than those with GG. Among these three SNPs, combination of SLC30A3 rs11126936 and SLC39A8 rs233804 may strongly affect blood zinc levels. This study is the first comprehensive investigation of the effect of SNPs in genes encoding zinc transporters on blood zinc concentration. Adverse effects of zinc deficiency are reported and above 3 SNPs may be related to genetic susceptibility to zinc deficiency.

引用

页码：28 / 33

页数：6

共 21 条

[1] Autosomal-Recessive Intellectual Disability with Cerebellar Atrophy Syndrome Caused by Mutation of the Manganese and Zinc Transporter Gene SLC39A8 [J].

Boycott, Kym M. ;

Beaulieu, Chandree L. ;

Kernohan, Kristin D. ;

Gebril, Ola H. ;

Mhanni, Aziz ;

Chudley, Albert E. ;

Redl, David ;

Qin, Wen ;

Hampson, Sarah ;

Kuery, Sebastien ;

Tetreault, Martine ;

Puffenberger, Erik G. ;

Scott, James N. ;

Bezieau, Stephane ;

Reis, Andre ;

Uebe, Steffen ;

Schumacher, Johannes ;

Hegele, Robert A. ;

McLeod, D. Ross ;

Galvez-Peralta, Marina ;

Majewski, Jacek ;

Ramaekers, Vincent T. ;

Nebert, Daniel W. ;

Innes, A. Micheil ;

Parboosingh, Jillian S. ;

Abou Jamra, Rami .

AMERICAN JOURNAL OF HUMAN GENETICS, 2015, 97 (06) :886-893

[2] EXCESSIVE ZINC INGESTION - A REVERSIBLE CAUSE OF SIDEROBLASTIC ANEMIA AND BONE-MARROW DEPRESSION [J].

BROUN, ER ;

GREIST, A ;

TRICOT, G ;

HOFFMAN, R .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1990, 264 (11) :1441-1443

[3] Differential cytolocation and functional assays of the two major human SLC30A8 (ZnT8) isoforms [J].

Carvalho, Sandra ;

Molina-Lopez, Jorge ;

Parsons, Douglas ;

Corpe, Christopher ;

Maret, Wolfgang ;

Hogstrand, Christer .

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 2017, 44 :116-124

[4] SLC30A3 and SEP15 gene polymorphisms influence the serum concentrations of zinc and selenium in mature adults [J].

da Rocha, Tatiane Jacobsen ;

Korb, Camila ;

Schuch, Jaqueline Bohrer ;

Bamberg, Daiani Pires ;

de Andrade, Fabiana Michelsen ;

Fiegenbaum, Marilu .

NUTRITION RESEARCH, 2014, 34 (09) :742-748

[5] The SLC39 family of metal ion transporters [J].

Eide, DJ .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2004, 447 (05) :796-800

[6]

Fujihara J, 2015, EUR REV MED PHARMACO, V19, P4920

[7]

Fujihara J., SURF REV LE IN PRESS

[8] Distribution and toxicity evaluation of ZnO dispersion nanoparticles in single intravenously exposed mice [J].

Fujihara, Junko ;

Tongu, Miki ;

Hashimoto, Hideki ;

Yamada, Takaya ;

Kimura-Kataoka, Kaori ;

Yasuda, Toshihiro ;

Fujita, Yasuhisa ;

Takeshita, Haruo .

JOURNAL OF MEDICAL INVESTIGATION, 2015, 62 (1-2) :45-50

[9] Replication study of the association of SNPs in the LHX3-QSOX2 and IGF1 loci with adult height in the Japanese population; wide-ranging comparison of each SNP genotype distribution [J].

Fujihara, Junko ;

Takeshita, Haruo ;

Kimura-Kataoka, Kaori ;

Yuasa, Isao ;

Iida, Reiko ;

Ueki, Misuzu ;

Nagao, Masataka ;

Kominato, Yoshihiko ;

Yasuda, Toshihiro .

LEGAL MEDICINE, 2012, 14 (04) :205-208

[10] The Zinc Transporter SLC39A13/ZIP13 Is Required for Connective Tissue Development; Its Involvement in BMP/TGF-β Signaling Pathways [J].

Fukada, Toshiyuki ;

Civic, Natacha ;

Furuichi, Tatsuya ;

Shimoda, Shinji ;

Mishima, Kenji ;

Higashiyama, Hiroyuki ;

Idaira, Yayoi ;

Asada, Yoshinobu ;

Kitamura, Hiroshi ;

Yamasaki, Satoru ;

Hojyo, Shintaro ;

Nakayama, Manabu ;

Ohara, Osamu ;

Koseki, Haruhiko ;

dos Santos, Heloisa G. ;

Bonafe, Luisa ;

Ha-Vinh, Russia ;

Zankl, Andreas ;

Unger, Sheila ;

Kraenzlin, Marius E. ;

Beckmann, Jacques S. ;

Saito, Ichiro ;

Rivolta, Carlo ;

Ikegawa, Shiro ;

Superti-Furga, Andrea ;

Hirano, Toshio .

PLOS ONE, 2008, 3 (11)

← 1 2 3 →