Medical implications of benzimidazole derivatives as drugs designed for targeting DNA and DNA associated processes

被引：144

作者：

Bhattacharya, Santanu ^{[1
,2
]}

Chaudhuri, Padmaparna ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

[2] Jawaharlal Nehru Ctr Adv Sci Res, Chem Biol Unit, Bangalore 560012, Karnataka, India

来源：

CURRENT MEDICINAL CHEMISTRY | 2008年 / 15卷 / 18期

关键词：

antibacterial; antihelminthic; DNA-alkylation; intercalation; major- and minor-groove; transcription factor; polymerase; helicase; topoisomerase;

D O I：

10.2174/092986708785133013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Properties of benzimidazole and its derivatives have been studied for over hundred years; special interest of researchers triggered by the fact that 5,6-dimethylbenzimidazole is a component of naturally occurring vitamin B-12. Several antihelminthic, antacid and antibacterial drugs are known which have benzimidazole moiety as their essential constituent. Additionally, several bis- and tris-benzimidazole based systems are well-known for their interaction with DNA and interference with several DNA associated processes. This account gives an overview of the benzimidazole based systems and their relevance in medicinal chemistry.

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页码：1762 / 1777

页数：16

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