Epigenetic Mechanisms in Asthma

被引：51

作者：

DeVries, Avery ^{[1
,2
]}

Vercelli, Donata ^{[2
,3
,4
,5
]}

机构：

[1] Univ Arizona, Grad Program Cellular & Mol Med, Tucson, AZ USA

[2] Univ Arizona, Funct Genom Lab, Arizona Resp Ctr, Tucson, AZ USA

[3] Univ Arizona, Arizona Ctr Biol Complex Dis, Tucson, AZ USA

[4] Univ Arizona, Dept Cellular & Mol Med, Tucson, AZ USA

[5] Univ Arizona, Inst Bio5, Tucson, AZ USA

来源：

ANNALS OF THE AMERICAN THORACIC SOCIETY | 2016年 / 13卷

关键词：

asthma; epigenetics; DNA methylation; CHILDHOOD ASTHMA; DNA METHYLATION; ALLERGY; EXPOSURE;

D O I：

10.1513/AnnalsATS.201507-420MG

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Asthma and allergic diseases are among the most prevalent chronic noncommunicable diseases of childhood, but the underlying pathogenetic mechanisms are poorly understood. Because epigenetic mechanisms link gene regulation to environmental cues and developmental trajectories, their contribution to asthma and allergy pathogenesis is under active investigation. DNA methylation signatures associated with concurrent disease and with the development of asthma during childhood asthma have been identified, but their significance is not easily interpretable. On the other hand, the characterization of early epigenetic predictors of asthma points to a potential role of epigenetic mechanisms in regulating the inception of, and the susceptibility to, this disease.

引用

页码：S48 / S50

页数：3

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