Synthesis and screening for antibacterial, analgesic and anti-inflammatory activity of Mannich bases derived from 1H-indole-2,3-dione

被引：0

作者：

Patro, V. J. ^{[1
]}

Panda, C. S. ^{[2
]}

Sahoo, B. M. ^{[1
]}

Mishra, N. K. ^{[1
]}

Panda, J. R. ^{[1
]}

机构：

[1] Roland Inst Pharmaceut Sci, Dept Pharmaceut Chem, Berhampur 760010, Orissa, India

[2] Indira Gandhi Inst Pharmaceut Sci, Dept Pharmaceut Chem, Bhubaneswar, Orissa, India

来源：

JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2012年 / 89卷 / 07期

关键词：

Schiff bases; Mannich bases; antibacterial; analgesic; anti-inflammatory; BETA-THIOSEMICARBAZONES; SCHIZOPYRENUS-RUSSELLI; CYSTICIDAL AGENTS; ISATIN; DERIVATIVES; ANTIFUNGAL; EXCYSTMENT;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction of isatin (1H-indole-2,3-dione) with substituted anilines in presence of acetic acid produces Schiff bases. Reaction of the Schiff bases with different secondary amines in presence of formaldehyde yields Mannich bases. The synthesized Mannich bases were screened for their antibacterial, analgesic and anti-inflammatory activities by the standard methods. The structures of the compounds were confirmed by means of physical and spectral data.

引用

页码：913 / 918

页数：6

共 28 条

[1]

[Anonymous], 1999, INDIAN DRUGS

[2]

EDDY NB, 1953, J PHARMACOL EXP THER, V107, P385

[3]

Et-Sawi E.A., 1998, J EGYPT SOC PARASITO, V28, P481

[4]

Ghosh MN., 1984, Fundamentals of Experimental Pharmacology, V2nd, P153

[5]

Gillespie S. H., 1994, MED MICROBIOLOGY ILL, V20, P234, DOI DOI 10.1016/B978-0-7506-0187-0.50025-0

[6]

GURSOY A, 1996, FARMACO, V39, P5072

[7]

IMAM SA, 1975, EXPERIENTIA, V31, P1287, DOI 10.1007/BF01945784

[8]

Laurence D. R., 1964, EVALUATION DRUG ACT, VI, P817

[9] ARENAVIRUS INACTIVATION ON CONTACT WITH N-SUBSTITUTED ISATIN BETA-THIOSEMICARBAZONES AND CERTAIN CATIONS [J].

LOGAN, JC ;

FOX, MP ;

MORGAN, JH ;

MAKOHON, AM ;

PFAU, CJ .

JOURNAL OF GENERAL VIROLOGY, 1975, 28 (SEP) :271-283

[10]

Nagarapu L, 1998, INDIAN J CHEM B, V37, P1254

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