Syntheses of new ruthenium (II and III)-nitroimidazole complexes

被引：2
作者：
Baird, Ian R. [1 ]
Skov, Kirsten A. [2 ]
James, Brian R. [1 ]
机构：
[1] Univ British Columbia, Dept Chem, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada
[2] British Columbia Canc Res Ctr, Adv Therapeut, Vancouver, BC V5Z 1L3, Canada
来源：
INORGANICA CHIMICA ACTA | 2019年 / 489卷
基金：
加拿大自然科学与工程研究理事会; 英国医学研究理事会;
关键词：
Nitroimidazoles; Metronidazole; Etanidazole; EF5; Ru complexes; X-RAY STRUCTURE; NITROIMIDAZOLE COMPLEXES; IMIDAZOLE COMPLEXES; MOLECULAR-STRUCTURE; SOLUTION CHEMISTRY; CRYSTAL-STRUCTURES; BINDING; DERIVATIVES; PORPHYRIN; AQUATION;
D O I：
10.1016/j.ica.2019.01.033
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Reactions of [Ru(DMF)(6)]Tf-3 with 2- and 5-nitroimidzoles, including the so-called metronidazole (metro), etanidazole (SR2508), and EF5, of known biological value, have been used to synthesize: (a) hydrates of the three new Ru-II complexes [RuL6]Tf-2,(L = 2NO(2)Im, 5NO(2)Im), and [Ru(2Me5NO(2)Im)(5)]Tf-2; and (b) the two new Ru-III complexes [Ru(DMF)(4)(SR2508)(2)]Tf-3 and [Ru(DMF)(2)(EF5)(2)(EtOH)(2)]Tf-3. Use of RuCl3 center dot 3H(2)O as precursor generates hydrates of the complexes: fac- and mer-RuCl3(2NO(2)Im)(3), mer-RuCl3(metro)(3), RuCl3(SR2508)(2)(EtOH), RuCl3(EF5)(2)(EtOH), and trans-RuCl2(metro)(4); a less well characterized complex is formulated RuCl3(2Me5NO(2)Im)(3)center dot 3CO(2) containing what appears to be adsorbed CO2.
引用
收藏
页码：100 / 107
页数：8
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