Cancer Cell Membrane-Biomimetic Nanoparticles for Homologous-Targeting Dual-Modal Imaging and Photothermal Therapy

被引：792

作者：

Chen, Ze ^{[1
]}

Zhao, Pengfei ^{[1
]}

Luo, Zhenyu ^{[1
,3
]}

Zheng, Mingbin ^{[1
,2
]}

Tian, Hao ^{[2
]}

Gong, Ping ^{[1
]}

Gao, Guanhui ^{[1
]}

Pan, Hong ^{[1
,3
]}

Liu, Lanlan ^{[1
]}

Ma, Aiqing ^{[2
]}

Cui, Haodong ^{[1
]}

Ma, Yifan ^{[1
]}

Cai, Lintao ^{[1
]}

机构：

[1] Chinese Acad Sci, Shenzhen Inst Adv Technol, Guangdong Key Lab Nanomed, CAS Key Lab Hlth Informat,Inst Biomed & Biotechno, Shenzhen 518055, Peoples R China

[2] Guangdong Med Univ, Guangdong Key Lab Res & Dev Nat Drugs, Dongguan 523808, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

ACS NANO | 2016年 / 10卷 / 11期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

cancer cell membrane; homologous targeting; dual-modal imaging; biomimetic nanoparticle; photothermal therapy; LIPID-POLYMER NANOPARTICLES; INDOCYANINE-GREEN; COATED NANOPARTICLES; DRUG-DELIVERY; BREAST-CANCER; AGGREGATION; CIRCULATION; VACCINATION; NANOSHELLS; STRATEGIES;

D O I：

10.1021/acsnano.6b04695

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An active cell membrane camouflaged nano particle, owning to membrane antigens and membrane structure, can achieve special properties such as specific recognition, long blood circulation, and immune escaping. Herein, we reported a cancer cell membrane cloaked nanoparticle system as a theranostic nanoplatform. The biomimetic nanoparticles (indocyanine green (ICG)-loaded and cancer cell membrane-coated nanoparticles, ICNPs) exhibit a core shell nanostructure consisting of an ICG-polymeric core and cancer cell membrane shell. ICNPs demonstrated specific homologous targeting to cancer cells with good monodispersity, preferable photothermal response, and excellent fluorescence/photoacoustic (FL/PA) imaging properties. Benefited from the functionalization of the homologous binding adhesion molecules from cancer cell membranes, ICNPs significantly promoted cell endocytosis and homologous-targeting tumor accumulation in vivo. Moreover, ICNPs were also good at disguising as cells to decrease interception by the liver and kidney. Through near infrared (NIR)-FL/PA dual-modal imaging, ICNPs could realize real-time monitored in vivo dynamic distribution with high spatial resolution and deep penetration. Under NIR laser irradiation, ICNPs exhibited highly efficient photothermal therapy to eradicate xenografted tumor. The robust ICNPs with homologous properties of cancer cell membranes can serve as a bionic nanoplatform for cancer-targeted imaging and phototherapy.

引用

页码：10049 / 10057

页数：9

共 40 条

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