Prospective evaluation of a rapid immunochromogenic cassette test for the diagnosis of melioidosis in northeast Thailand

被引：29
作者：
Cheng, AC
Peacock, SJ
Limmathurotsakul, D
Wongsuvan, G
Chierakul, W
Amornchai, P
Getchalarat, N
Chaowagul, W
White, NJ
Day, NPJ
Wuthiekanun, V
机构：
[1] Mahidol Univ, Fac Trop Med, Bangkok 10400, Thailand
[2] Flinders Univ S Australia, No Terr Clin Sch, Darwin, NT, Australia
[3] Charles Darwin Univ, Menzies Sch Hlth Res, Darwin, NT, Australia
[4] Sappasithiprasong Univ, Dept Med, Ubon Ratchathani, Thailand
[5] Univ Oxford, Ctr Clin Vaccinol & Trop Med, Nuffield Dept Clin Med, Oxford OX3 7LJ, England
来源：
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2006年 / 100卷 / 01期
基金：
英国惠康基金;
关键词：
melioidosis; Burkholderia pseudomallei; immunochromogenic cassette test; indirect haemagglutination assay; Thailand;
D O I：
10.1016/j.trstmh.2005.04.019
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
A prospective study was performed to compare a rapid immunochromogenic cassette test (ICT) with the indirect haemagglutination assay (IHA) and clinical rules for the diagnosis of melioidosis in an endemic area. The sensitivity and specificity of the IgG ICT was 86% and 47%, and the IgM ICT was 82% and 47%, respectively. These were similar to the results for IHA (sensitivity 73%, specificity 64%) and clinical rules (73% and 37%). ICT lacks clinical utility as a result of high background rates of positive Burkholderia pseudomallei serology in this population. Low sensitivity and specificity of clinical rules is consistent with the protean manifestations of melioidosis and clinical difficulty in identifying patients with melioidosis. (c) 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：64 / 67
页数：4
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