Associations of tumor regression grade with outcomes in patients with locally advanced rectal cancer treated with preoperative two-week course of radiotherapy

被引：2
作者：
Li, Yong-Heng [1 ]
Li, Jin-Luan [2 ]
Zhu, Xiang-Gao [1 ]
He, Jun-Yan [3 ]
Lin, Li-Mei [4 ]
Lin, Xiao-Yi [5 ]
Tang, Li-Rui [2 ]
Cai, Yong [1 ]
机构：
[1] Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Dept Radiat Oncol,Minist Educ Beijing, Beijing, Peoples R China
[2] Fujian Med Univ, Canc Hosp, Fujian Canc Hosp, Dept Radiat Oncol, Fuzhou, Fujian, Peoples R China
[3] Univ South China, Dept Biochem & Mol Biol, Hengyang, Peoples R China
[4] Xiamen Univ, Affiliated Xiamen Hosp 1, Xiamen, Peoples R China
[5] Xiamen Humanity Hosp, Xiamen, Peoples R China
来源：
ONCOTARGET | 2017年 / 8卷 / 59期
关键词：
tumor regression grade; two-week course; radiotherapy; rectal cancer; prognosis; DISEASE-FREE SURVIVAL; PATHOLOGICAL RESPONSE; NEOADJUVANT THERAPY; PROGNOSTIC VALUE; CHEMORADIOTHERAPY; RADIOCHEMOTHERAPY; CARCINOMA; CHEMORADIATION; RADIATION; ADENOCARCINOMA;
D O I：
10.18632/oncotarget.22118
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose: Studies concerning tumor regression grade (TRG) after two-week course of radiotherapy (RT) are limited. We tried to assess associations of TRG and outcomes in patients with locally advanced rectal cancer (LARC) treated with preoperative two-week course of RT. Methods: 356 consecutive LARC patients were retrospectively assessed. Patients with complete/intermediate (TRG1-3) and poor (TRG4-5) regressions were compared for overall survival (OS), disease-free survival (DFS) and metastasis-free survival (MFS). Results: By univariate analysis, pretreatment and postoperative factors including TNM stages, ypT, ypN, surgical procedure, pathological grade, and TRG impacted survival outcomes. Complete/intermediate regressions (TRG1-3) had significantly improved survival outcomes compared with poor ones (TRG4-5) (5y-OS, 85.8% vs. 65.8%, P=0.001; 5y-DFS, 76.0% vs. 53.7%, P<0.001; 5y-MFS, 84.2% vs. 66.7%, P<0.001). Multivariate analysis showed that ypN (P<0.001) and pathological grade (P=0.018) were the most important independent prognostic factors for DFS. ypT (P=0.014) and ypN (P=0.001) were the independent prognostic factors for MFS. Meanwhile, ypT (P=0.009), ypN (P=0.001), surgical procedure (p=0.001), and TRG (p=0.019) were the independent prognostic factors for OS. Conclusions: Complete/intermediate TRG regressions had a more favorable prognosis than the poor group. When treated with preoperative two-week course of RT; ypT, ypN, surgical procedure, and TRG seem to affect OS.
引用
收藏
页码：100165 / 100175
页数：11
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