Chemopreventive activity of isoquinoline alkaloids from Corydalis plants

被引：27

作者：

Ito, C

Itoigawa, M

Tokuda, H

Kuchide, M

Nishino, H

Furukawa, H ^{[1
]}

机构：

[1] Meijo Univ, Fac Pharm, Tempaku Ku, Nagoya, Aichi 4688503, Japan

[2] Tokyo Gakuen Univ, Miyoshi, Aichi, Japan

[3] Kyoto Prefectural Univ Med, Dept Biochem, Kyoto 602, Japan

来源：

PLANTA MEDICA | 2001年 / 67卷 / 05期

关键词：

D O I：

10.1055/s-2001-15815

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eighteen isoquinoline alkaloids including protoberberines (1-12), benzophenanthridines (13-16) and an aporphine (17) isolated from plants of Corydalis species (Fumariaceae) were tested for inhibitory effects on Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol 13-acetate in Raji cells. In a primary screening test, all of the isoquinoline alkaloids showed inhibitory activity with the IC50 values being in the range of 140-410 mol ratio/32 pmol TPA. The data demonstrate that these isoquinoline alkaloids might be valuable as anti-tumor promoters.

引用

页码：473 / 475

页数：3

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