The Complex Interplay between Antioxidants and ROS in Cancer

被引：493
作者：
Harris, Isaac S. [1 ,2 ]
DeNicola, Gina M. [3 ]
机构：
[1] Univ Rochester, Med Ctr, Dept Biomed Genet, 601 Elmwood Ave, Rochester, NY 14642 USA
[2] Univ Rochester, Med Ctr, Wilmot Canc Inst, 601 Elmwood Ave, Rochester, NY 14642 USA
[3] H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Physiol, Tampa, FL 33612 USA
来源：
TRENDS IN CELL BIOLOGY | 2020年 / 30卷 / 06期
关键词：
GLUTATHIONE-S-TRANSFERASE; TRANSCRIPTION FACTOR NRF2; OXIDATIVE STRESS; VITAMIN-E; CELL-PROLIFERATION; HYDROGEN-PEROXIDE; PROSTATE-CANCER; LUNG-CANCER; CHEMICAL BIOLOGY; DNA-DAMAGE;
D O I：
10.1016/j.tcb.2020.03.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Reactive oxygen species (ROS) play important roles in tissue homeostasis, cellular signaling, differentiation, and survival. In this review, we discuss the types of ROS, their impact on cellular processes, and their pro- and antitumorigenic effects. Further, we discuss recent advances in our understanding of both endogenous and exogenous antioxidants in tumorigenic processes. Finally, we discuss how aberrant activation of antioxidant programs by the transcription factor NFE2-related factor 2 (NRF2) influences tumorigenesis and metastasis, and where the current gaps in our knowledge remain.
引用
收藏
页码：440 / 451
页数：12
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